Course Descriptions

BME 2000 Intro to BME Design & Discovery
BME 2101 Physiology for Engineers I
BME 2102 Physiology for Engineers II
BME 2104 Cell & Molecular Biology for Engineers
BME 2220 Biomechanics
BME 2315 Computational BME
BME 3240 Biotransport
BME 3310 Biomedical Systems Analysis & Design
BME 3636 Neural Network Models of Cognition and Brain Computation
BME 3080, 3090 BME Integrative Design & Experimental Analysis (IDEAS) Lab I & II
BME 4806 Biomedical Applications of Genetic Engineering
BME 4414 Biomaterials
BME 4417 Tissue Engineering
BME 4280 Motion Biomechanics
BME 4641 Bioelectricity
BME 4995 BME Advanced Projects
BME 4063, 4064 Biomedical Engineering Capstone Design I & II
BME 4783 Medical Image Modalities
BME 4784 Medical Image Analysis
BME 4890 Nanomedicine
BME 4550 Special Topics in Biomedical Engineering
BME 4550 Medical Imaging Systems Theory
BME 4550 Quantitative Biological Reasoning
BME 4550 Systems Bioengineering Modeling and Experimentation
BME 4550 BME Electronics Lab
BME 4550 BME Advanced Design
BME 4550 Orthopedic and Injury Biomechanics
BME 4993 Independent Study

BME 2000 - (3) REQUIRED, Fall
Intro to BME Design & Discovery
Prerequisite: CS 1110, PHYS 1425, and ENGR 1620, or instructor permission. Provides an overview of the BME discipline and major sub-disciplines (biomechanics, genetic engineering, tissue engineering, bioelectricity, imaging, cellular engineering, computational systems biology), covers conceptual and detail design processes, and introduces quantitative tools utilized throughout the BME curriculum. Includes formulation and execution of a major design project.

BME 2101 - (3) REQUIRED, Fall
Physiology for Engineers I
Prerequisite: CHEM 1610, and PHYS 1425, or instructor permission. Studies how excitable tissue, nerves and muscle, and the cardiovascular and respiratory systems work. Focuses on understanding mechanisms and includes an intro to structure, an emphasis on quantitative function, and integration of hormonal and neural regulation and control.

BME 2102 - (3) REQUIRED, Spring
Physiology for Engineers II
Prerequisite: BME 2101, or instructor permission.
Introduces the physiology of the kidney, salt and water balance, gastrointestinal system, endocrine system, and central nervous system, with reference to diseases and their pathophysiology.

BME 2104 - (3) REQUIRED, Spring
Cell & Molecular Biology for Engineers
Prerequisite: CHEM 1610 and BIOL 2101, or instructor permission. Introduces the fundamentals of cell structure and function, emphasizing the techniques and technologies available for the study of cell biology. A problem-based approach is used to motivate each topic. Divided into three general sections: cell structure and function includes cell chemistry, organelles, enzymes, membranes, membrane transport, intracellular compartments and adhesion structures; energy flow in cells concentrates on the pathways of glycolysis and aerobic respiration; information flow in cells focuses on modern molecular biology and genetic engineering, and includes DNA replication, the cell cycle, gene expression, gene regulation, and protein synthesis. Also presents specific cell functions, including movement, the cytoskeleton and signal transduction. Students may not receive credit for both CHE 2246 and BME 2104.

BME 2220 - (3) REQUIRED, Spring
Prerequisite: APMA 2120, 2130, and BME 2101, or instructor permission. Introduces the principles of continuum mechanics of biological tissues and systems. Topics include 1) review of selected results from statics and strength of materials, continuum mechanics, free-body diagrams, constitutive equations of biological materials, viscoelastic models, and fundamental concepts of fluid mechanics and mass transport; 2) properties of living tissue; 3) mechanical basis and effects of pathology and trauma, 4) introduction to mechanotransduction, circulatory transport, growth and remodeling, and tissue-engineered materials, and 5) low Reynolds number flows in vivo and in microsystems.

BME 2315 - (3) REQUIRED, Spring
Computational BME
Prerequisite: BME 2101, 2104, and 2220, or instructor permission. Introduces techniques for constructing predictive or analytical engineering models for biological processes. Teaches modeling approaches using example problems in transport, mechanics, bioelectricity, molecular dynamics, tissue assembly, and imaging. Problem sets will include 1) linear systems and filtering, 2) compartmental modeling, 3) numerical techniques, 4) finite element / finite difference models, and 5) computational automata models.

BME 3240 - (3) REQUIRED, Spring
Prerequisite: APMA 2120, 213, BME 2101, 2104 or equivalent, or instructor permission. Corequisite: BME 2220. Biotransport in biological living systems is a fundamental phenomenon important in all aspects of the life cycle. Course will introduce principles and application of fluid and mass transport processes in cell, tissue and organ systems. Topics include introduction to physiological fluid mechanics in the circulation and tissue, fundamentals of mass transport in biological systems, effects of mass transport and biochemical interactions at the cell and tissue scales, and fluid and mass transport in organs.

BME 3310 - (3) REQUIRED, Fall
Biomedical Systems Analysis & Design
Prerequisites: APMA 2130, CS 1110, and PHYS 1425, or instructor permission. Presents the analytical tools used to model signals and linear systems. Specific biomedical engineering examples include multicompartment modeling of drug delivery, modeling of dynamic biomechanical systems, and electrical circuit models of excitable cells. Major topics include terminology for signals and systems, convolution, continuous time Fourier transforms, electrical circuits with applications to bioinstrumentation and biosystems modeling, and applications of linear system theory. Students may not receive credit for both ECE 3750 and BME 3310.


BME 3636 - (3) ELECTIVE, Spring
Neural Network Models of Cognition and Brain Computation
Cross-listed as PSYC 5330. Prerequisite: CS 1110, BME 2101, or instructor permission. Introduction to neural networks research, specifically biologically-based networks that reproduce cognitive phenomena. The goal is to teach the basic thinking and methodologies used in constructing and understanding neural-like networks.

BME 3080, 3090 - (4+4) REQUIRED, Fall, Spring
BME Integrative Design & Experimental Analysis (IDEAS) Lab I & II
Prerequisite: BME 2101, 2104, and 2220, and 3rd year standing in the BME major, or Inst. permission. Co-requisite: BME 3310, 2315, 3240. Year-long course to integrate concepts and skills from prior courses in order to formulate and solve problems in biomedical systems, including experimental design, performance, and analysis. Lab modules include testing in tissues/cells and manipulation of molecular constituents of living systems to determine their structural and functional characteristics for design of therapeutic or measurement systems. Methods include biochemical, physiological, cell biology, mechanical, electrical and computer, systems, chemical, imaging, and other approaches.

BME 4806 - (3) ELECTIVE, Spring
Biomedical Applications of Genetic Engineering
Prerequisite: BME 2101, 2102, and 2104, and 3rd/4th year standing, or instructor permission. Provides a grounding in molecular biology and a working knowledge of recombinant DNA technology, thus establishing a basis for the evaluation and application of genetic engineering in whole animal systems. Beginning with the basic principles of genetics, this course examines the use of molecular methods to study gene expression, deliver viral and non-viral vectors, and its critical role in health.

BME 4414 - (3) ELECTIVE, Fall
Prerequisite: BME 2101, 2104 or equivalent, 3rd or 4th year standing, or instructor permission. This course will provide an introduction to biomaterials science and biological interactions with materials, including an overview of biomaterials testing and characterization. The emphasis of this course, however, will be on emerging novel strategies and design considerations of biomaterials. Areas of concentration will include the use of polymers and ceramics in biomaterials today, drug delivery applications, tissue engineering from both an orthopaedic and vascular perspective, and nanotechnology related to biomaterials. Specific attention will also be paid to the in vitro and in vivo testing of biomaterials, and a review of current research in the field.

BME 4417 - (3) ELECTIVE, Spring
Tissue Engineering 
Prerequisite: APMA 2130, BME 2101, and 2104 or equivalent, or instructor permission. Introduces the fundamental principles of tissue engineering. Topics include: tissue organization and dynamics, cell and tissue characterization, cell-matrix interactions, transport processes in engineered tissues, biomaterials and biological interfaces, stem cells and interacting cell fate processes, and tissue engineering methods. Examples of tissue engineering approaches for regeneration of cartilage, bone, ligament, tendons, skin and liver are presented.

BME 4280 - (3) ELECTIVE, Spring
Motion Biomechanics
Prerequisite: BME 2101, 2220, or instructor permission. Focuses on the study of forces (and their effects) that act on the musculoskeletal structures of the human body. Based on the foundations of functional anatomy and engineering mechanics (rigid body and deformable approaches); students are exposed to clinical problems in orthopedics and rehabilitation.

BME 4641 - (3) ELECTIVE, Fall
Prerequisite: BME 3310 or ECE 2630, BME 2101, or instructor permission. Studies the biophysical mechanisms governing production and transmission of bioelectric signals, measurement of these signals and their analysis in basic and clinical electrophysiology. Introduces the principles of design and operation of therapeutic medical devices used in the cardiovascular and nervous systems. Includes membrane potential, action potentials, channels and synaptic transmission, electrodes, electroencephalography, electromyography, electrocardiography, pacemakers, defibrillators, and neural assist devices.

BME 4995 - (1-3) ELECTIVE, Fall, Spring
BME Advanced Projects
Prerequisite: instructor permission and approval of the BME Undergraduate Program Director using the form in the BME Research Guide (available online and in MR5 2010). Research project in biomedical engineering conducted in consultation with a department faculty advisor, usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Only 3 credits (total) of BME 4995 will count as either a Bioengineering or BME elective. Another 3 credits count as an Unrestricted Elective.

BME 4063, 4064 - (3+3) REQUIRED, Fall, Spring
Biomedical Engineering Capstone Design I & II
Prerequisite: Fourth year standing in BME major, or instructor permission. A year-long design project in biomedical engineering required for BME majors. Students select, formulate, and solve a design problem related to a device or a system. Projects use conceptual design, skills obtained in the integrated lab, and substantial literature and patent reviews. Projects may be sponsored by BME faculty, medical doctors, and/or companies. Students may work on their own with outside team members when appropriate or with other SEAS students in integrative teams.


BME 4783 - (3) ELECTIVE, Fall
Medical Image Modalities  (not offered Fall 2009)

BME 4784 - (4) ELECTIVE, Spring
Medical Image Analysis (not offered Spring 2010)

BME 4890 - (3) ELECTIVE, Fall
Prerequisite: BME 2104 or CHE 2246, BME 2220, or 4th year standing, or instructor permission. Recommended: BME 3240 or CHE 3321. Students will design treatment strategies for cancer and cardiovascular disease based on molecular bioengineering principles. Special topics will include design of nanoparticle drug and gene delivery platforms, materials biocompatibility, cancer immunotherapy, and molecular imaging.

BME 4550 - (3+3) ELECTIVE, Fall, Spring
Special Topics in Biomedical Engineering
Prerequisite: varies. Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering.

BME 4550 - (3) ELECTIVE, Fall
Medical Imaging Systems Theory
Prerequisite: ECE 3750 or BME 3310 or equivalent exposure to linear systems theory, and instructor permission. Develops an intuitive understanding of the mathematical systems theory needed to understand and design biomedical imaging systems, including ultrasound, magnetic resonance imaging and computed tomography. Emphasis is on 2D continuous systems, but 1D and discrete systems are also covered. Topics include multidimensional Fourier transform theory, image reconstruction techniques, diffraction theory, and Fourier optics.

BME 4550 - (3) ELECTIVE, Fall
Quantitative Biological Reasoning
Prerequisite: 4th year standing and instructor permission. Provides students with a quantitative framework for identifying and addressing important biological questions at the molecular, cell, and tissue levels. Part I covers methods, with an emphasis on the biochemical, biophysical, and mathematical themes that emerge repeatedly in quantitative experiments. Discussions will be preceded by primary literature that illustrate how in-depth understanding of such themes led to significant conceptual advances in biochemistry, molecular biology, and cell biology. Part II will focus on how quantitative methods combine to aid scientific logic. Topics will include practical implementations of the scientific method, falsification of hypotheses, and strong inference. Course concludes with an introduction to how quantitative biological reasoning can be effectively presented through scientific writing and information design.

BME 4550 - (3) ELECTIVE, Fall
Systems Bioengineerng Modeling and Experimentation
Prerequisite: Fourth year standing in BME major, or instructor permission. Introduces techniques for constructing mathematical and computational models of vascular biological processes and utilizing experimental methods to validate those models at many levels of organizational scale, from genome to whole-tissue. Students rotate through three modules where they attend lectures, read literature, and participate in discussions focused on various modeling and experimental validation techniques. In each module, they work in teams of three to complete group modeling projects that apply the modeling techniques specific to the particular module. Teams will also conduct experiments relevant to the biological question of each module. Topics to be covered include choice of modeling techniques appropriate to addressing particular biological problems at different scales, quantitative characterization of biological properties, assumptions and model simplification, parameter estimation and sensitivity analysis, model verification and validation, and integration of computational modeling with experimental approaches.

BME 4550 - (3) ELECTIVE, Spring
BME Electronics Lab
Prerequisite: 2nd year standing. Course objectives: (1) To provide an understanding of basic techniques involving electrical and electronic circuit analysis; and (2) To enable students to apply the knowledge and techniques in electrical systems to problems in biomedical engineering. These goals will be achieved through lectures and labs in combination.

BME 4550 - (3) ELECTIVE, Spring
BME Advanced Design
Prerequisite: BME 2000 and instructor permission. Project-driven course focusing on biomedical product design, with an emphasis on marketability, innovation, entrepreneurship, and business. Topics covered include design fundamentals, problem/needs identification, delineation of realistic constraints and product specifications, intellectual property, market analysis, entrepreneurship, specific advanced design topics (e.g. design for manufacturing, cradle-to-grave product lifecycle analysis, etc.), business plan development, venture funding, and medical product testing methods.

BME 4550 - (3) ELECTIVE, Spring
Orthopedic and Injury Biomechanics
Prerequisite: Instructor permission. In this course students will gain working knowledge of the functions and mechanical properties, including failure, of musculoskeletal tissues, how those tissue combine to form structures, the properties and behavior of those structures, the role of mechanical forces in the formation, morphology, nature, and injury of those material and structures, and the failure mechanics and thresholds of anatomical structures in the head, neck, thorax, abdomen, and extremities.

BME 4993 - (1-3) ELECTIVE, Fall, Spring
Independent Study
Prerequisite: instructor permission. In-depth study of a biomedical engineering area by an individual student in close collaboration with a departmental faculty member. Requires advanced analysis of a specialized topic in biomedical engineering that is  not covered by current offerings. Requires faculty contact time and assignments comparable to regular course offerings. Requires approval by UG Program Director. Use form on p 16.