The Skalak Laboratory

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Megan E. Doyle    /

I have been in the Department of Biomedical Engineering here at UVA for the past five years. I received my undergraduate degree in Chemical Engineering from the University of Texas at Austin. When I'm not making really exciting scientific discoveries in the lab, I like to hang out at home with my husband, my army of animals, and my TIVO.

University of Virginia
PhD Candidate, Biomedical Engineering, 2002 - present

University of Texas at Austin
Bachelor of Science, Chemical Engineering, May 2002

Research Interests
Microvascular adaptations occur through the processes of angiogenesis, arteriogenesis, and venogenesis in response to both physiological and pathological stimuli. Delivery of cells, specifically bone marrow-derived cells, is actively investigated as a means to stimulate the growth of new vasculature, and/or enlargement of pre-existing vessels. Understanding how bone marrow-derived cells impact all components of the microvascular network is important in determining their value as a therapeutic agent, but their ability to augment remodeling on the venule side of the network lacks attention. I study how the delivery of bone marrow-derived cells to a remodeling tissue can influence the processes of angiogenesis, arteriogenesis and venogenesis, and how the dynamics of these events might influence overall microvascular network function. Specifically, I am investigating how and why venules enlarge in response to the delivery of bone marrow-derived progenitor cells, and am working to identify the molecular mechanism by which bone marrow-derived cell delivery drives venous remodeling.