Heart function and disease are controlled by complex molecular networks that are just beginning to be mapped out. Our lab develops mathematical models to understand how these molecular control systems work, and then we perform a variety of experiments to test this understanding. Experimental techniques include cell culture, live-cell imaging, and biochemical assays. These integrated approaches are helping us harness molecular networks to reverse the progression of heart disease.
Current projects include:
- Beta-adrenergic signaling and novel therapies in heart failure
- Live-cell imaging of cAMP compartmentation
- Multi-scale modeling of signaling networks
- Calcium signaling pathways regulating heart contractility and growth
- Diagnosis of neonatal sepsis by its actions on the heart