Peer-Reviewed Publications

  1. Ryall KA, Holland DO, Delaney KA, Kraeutler MJ, Parker AJ, Saucerman JJ. Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling. J Biol Chem. 2012 Oct 22. [Pubmed]
  2. Cui WY, Zhao S, Polanowska-Grabowska R, Wang J, Wei J, Dash B, Chang SL, Saucerman JJ, Gu J, Li MD. Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages. Mol Pharmacol, published ahead of print October 1, 2012, doi:10.1124/mol.112.081497.
  3. Ryall KA, *Saucerman JJ. Automated imaging reveals a concentration-dependent delay in reversibility of cardiac myocyte hypertrophy. J Mol Cell Cardiol, 2012 53(2):282-90. PMCID: 3389167. [Pubmed]
  4. Yang JH, Saucerman JJ. Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy. J Mol Cell Cardiol. 2012; 52(5):1048-55. PMCID: 3327824. [Pubmed]
  5. 1Sample V, 1DiPilato LM, 1Yang JH, Ni Q, Saucerman JJ, Zhang J. Regulation of nuclear PKA revealed by spatiotemporal manipulation of cAMP. Nature Chemical Biology. 2012;8(4):375-82. PMCID: 3307945. [Pubmed]
  6. Bass GT, Ryall KA, Katikapalli A, Taylor BE, Dang ST, Acton ST, Saucerman JJ. Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy. J Mol Cell Cardiol. 2012; 52(5):923-30. PMCID: 3299901. [Link]
  7. Raynor LL, Saucerman JJ, Akinola MO, Lake DE, Moorman JR, Fairchild KD. Cytokine screening identifies NICU patients with Gram-negative bacteremia. Pediatric Research. 2012;71(3):261-6.

  8. Amanfu RK, Saucerman JJ. Cardiac models in drug discovery and development: a review. Crit Rev Biom Eng 2011. [Pubmed]
  9. Amanfu, RK, Muller, J, Saucerman JJ. Automated image analysis of cardiac myocyte Ca2+ dynamics. Conf Proc IEEE Eng Med Biol Soc 2011. [Pubmed]
  10. Haggart CR, Bartell JA, Saucerman JJ, Papin JA. Whole-genome metabolic network reconstruction and constraint-based modeling. Methods Enzymol. 2011;500:411-33. [Pubmed]
  11. Holland DO, Krainak NC, Saucerman JJ. Graphical approach to model reduction for nonlinear biochemical networks. PLoS One. 2011;6(8):e23795. Epub 2011 Aug 25. [Pubmed]
  12. Soltis AR, Saucerman JJ. Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty. Bioinformatics. 2011 Oct 15;27(20):2888-94. Epub 2011 Aug 31. [Pubmed]
  13. Saucerman JJ, Bers DM. "Calmodulin binding proteins provide domains of local Ca(2+) signaling in cardiac myocytes." J Mol Cell Cardiol. 2011 Jun 12. [Epub ahead of print] [Pubmed]
  14. Greenwald EC, Saucerman JJ. Bigger, Better, Faster: Principles and Models of AKAP Anchoring Protein Signaling. J Cardiovasc Pharmacol. 2011 Nov;58(5):462-9. [Pubmed]
  15. Yang JH, Saucerman JJ. "Computational models reduce complexity and accelerate insight into cardiac signaling networks." Circ Res. 2011;108(1):85-97. [Pubmed]
  16. Benedict KF, Mac Gabhann F, Amanfu RK, Chavali AK, Gianchandani EP, Glaw LS, Oberhardt MA, Thorne BC, Yang JH, Papin JA, Peirce SM, Saucerman JJ, Skalak TC. "Systems Analysis of Small Signaling Modules Relevant to Eight Human Diseases." Ann Biomed Eng. 2011;39(2):621-35. [Pubmed]

  17. Kraeutler MJ, Soltis AR, Saucerman JJ. "Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model." BMC Syst Biol. 2010;4:157. [Pubmed]
  18. Soltis AR, Saucerman JJ. "Synergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling." Biophys J. 2010;99(7):2038-47. [Pubmed]. Selected as a “Must Read” 8/10 by [Faculty of 1000].

  19. Fairchild KD, Saucerman JJ, Raynor LL, Sivak JA, Xiao Y, Lake DE, Moorman JR. "Endotoxin depresses heart rate variability in mice: cytokine and steroid effects." Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1019-27. [Pubmed]. Featured by [UVA Today].
  20. Lu S, Michailova A, Saucerman J, Cheng Y, Yu Z, Kaiser T, Li W, Bank R, Holst M, McCammon J, Hayashi T, Hoshijima M, Arzberger P, McCulloch A. "Multiscale modeling in rodent ventricular myocytes." IEEE Eng Med Biol Mag. 2009 Mar-Apr;28(2):46-57. [Pubmed]
  21. Szafaryn LG, Skadron K, Saucerman JJ. Experiences accelerating MATLAB systems biology applications. Proceedings of the Workshop on Biomedicine in Computing: Systems, Architectures, and Circuits (BiC) in conjunction with the 36th IEEE/ACM International Symposium on Computer Architecture (ISCA); June 2009; Austin, TX. [PDF]
  22. Yang J. "Science Careers: Where does advocacy fit?" Science. 2009; 323(5911):208-209. [Pubmed]

  23. Song Q, Saucerman JJ, Bossuyt J, Bers DM. "Differential integration of Ca-calmodulin signal in intact ventricular myocytes at low and high affinity Ca-calmodulin targets." J Biol Chem. 2008 Nov 14;283(46):31531-40. [Pubmed]
  24. Saucerman JJ, Bers DM. "Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes." Biophys J. 2008 Nov 15;95(10):4597-612. [Pubmed]

  25. Saucerman JJ, McCulloch AD. "Cardiac beta-Adrenergic Signaling: From Subcellular Microdomains to Heart Failure." Ann N Y Acad Sci. 2006 Oct;1080:348-61. [Pubmed]
  26. Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. "Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes." Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12923-8. [Pubmed]

  27. Michailova A, Saucerman J, Belik ME, McCulloch AD. "Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+." Biophys J. 2005 Mar;88(3):2234-49. [Pubmed]
  28. Erdemir A, Saucerman JJ, Lemmon D, Loppnow B, Turso B, Ulbrecht JS, et al. Local plantar pressure relief in therapeutic footwear: design guidelines from finite element models. J Biomech. 2005;38(9):1798-806. [Pubmed]

  29. Saucerman JJ, Healy SN, Belik ME, Puglisi JL, McCulloch AD. "Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue." Circ Res. 2004 Dec 10;95(12):1216-24. [Pubmed]
  30. Saucerman JJ, McCulloch AD. "Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation." Prog Biophys Mol Biol. 2004 Jun-Jul;85(2-3):261-78. [Pubmed]

  31. Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. "Modeling beta-adrenergic control of cardiac myocyte contractility in silico." J Biol Chem. 2003 Nov 28;278(48):47997-8003. [Pubmed]

Book Chapters, Editorials

  1. Saucerman JJ. Cardiac biexcitability: Two ways to catch a wave. Heart Rhythm. 2011 Sep 3. [Epub ahead of print] [Pubmed]
  2. Saucerman JJ, Zhang J. Subcellular signaling dynamics. In: Wall ME, editor. Quantitative Biology: From Molecular to Cellular Systems: CRC Press; 2011, in press.