Image Analysis
Ryall KA, *Saucerman JJ. Automated imaging reveals a concentration-dependent delay in reversibility of cardiac myocyte hypertrophy. J Mol Cell Cardiol, 2012 53(2):282-90. PMCID: 3389167. [Pubmed]
Bass GT, Ryall KA, Katikapalli A, Taylor BE, Dang ST, Acton ST, Saucerman JJ. Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy. J Mol Cell Cardiol. 2012; 52(5):923-30. PMCID: 3299901. [Link]
CellProfiler is developed by Anne Carpenter at the Broad Institute and should be downloaded at [link]. Our data was processed using CellProfiler Developer build 1.0.7522 [download].
Amanfu, RK, Muller, J, Saucerman JJ. Automated image analysis of cardiac myocyte Ca2+ dynamics. Conf Proc IEEE Eng Med Biol Soc 2011. [Pubmed]
Computational Models
Ryall KA, Holland DO, Delaney KA, Kraeutler MJ, Parker AJ, Saucerman JJ. Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling. J Biol Chem. 2012 Oct 22. [Pubmed]
Yang JH, Saucerman JJ. Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy. J Mol Cell Cardiol. 2012; 52(5):1048-55. PMCID: 3327824. [Pubmed]
Holland DO, Krainak NC, Saucerman JJ. Graphical approach to model reduction for nonlinear biochemical networks. PLoS One. 2011;6(8):e23795. Epub 2011 Aug 25. [Pubmed]
Soltis AR, Saucerman JJ. "Synergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling." Biophys J. 2010;99(7):2038-47. [Pubmed]. Selected as a “Must Read” 8/10 by [Faculty of 1000].
Saucerman JJ, Bers DM. "Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes." Biophys J. 2008 Nov 15;95(10):4597-612. [Pubmed]
Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. "Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes." Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12923-8. [Pubmed]
Saucerman JJ, Healy SN, Belik ME, Puglisi JL, McCulloch AD. "Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue." Circ Res. 2004 Dec 10;95(12):1216-24. [Pubmed]
Saucerman JJ, McCulloch AD. "Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation." Prog Biophys Mol Biol. 2004 Jun-Jul;85(2-3):261-78. [Pubmed]
Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. "Modeling beta-adrenergic control of cardiac myocyte contractility in silico." J Biol Chem. 2003 Nov 28;278(48):47997-8003. [Pubmed]