Heart function and failure are controlled by complex signaling and transcriptional networks that are just beginning to be mapped out. Our lab combines computational modeling and live-cell microscopy to identify these molecular networks and understand how they mediate cell decisions.

We are tackling a number of unexplained cellular decisions that are fundamental to the development of heart failure. For example, after myocardial infarction, what causes a given myocyte to choose enhanced contractility, growth, or death? Why do certain stresses cause myocyte lengthening, while other stresses increase myocyte thickness? Why are certain forms of heart growth reversible while others are irreversible? Answers to these basic science questions are being translated into novel strategies to re-engineer the failing heart.

News:
SauceLab on Twitter (link)
UVA BME Department news (link)

January 2016:
Congratulations and farewell to Will Richardson, who is starting his new lab at Clemson!

Article including our high-content imaging in GEN: link

Positions Available:
Graduate Students - apply to UVA Biomedical Engineering here and email Dr. Saucerman for more information about specific opportunities.

Post-doc and Undergrad Students - email Dr. Saucerman for more information