Heart function and failure are controlled by complex signaling and transcriptional networks that are just beginning to be mapped. Our lab combines computational modeling and high-throughput experiments to discover molecular networks and drugs for heart failure.

We are tackling a number of unexplained cellular decisions that are fundamental to the development of heart failure. For example, after myocardial infarction, what causes a given myocyte to choose enhanced contractility, growth, or death? How do fibroblasts interpret complex cues to modulate extracellular matrix composition? Why do certain stresses cause myocyte lengthening, while other stresses increase myocyte thickness? Why are certain forms of heart growth reversible while others are irreversible? Can developmental programs be reactivated for cardiac regeneration? Answers to these basic science questions are being translated into novel strategies to re-engineer the failing heart.

News:
SauceLab on Twitter (link)
UVA BME Department news (link)

October 2016:
Nice article on Angela and Ani's Double Hoo Award https://t.co/JNzRvg7xmi.

September 2016:
Congratulations to Angela Zeigler and Bryan Chun, who were both awarded NIH F30 Individual Predoctoral MD/PhD Fellowships!

May 2016:
Congratulations on Angela Zeigler, who has received an AHA predoctoral fellowship! Angela also recently published her paper "A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation." in the Journal of Molecular and Cellular Cardiology (link)

April 2016:
Congrats to Ani Chandrabhatla and Angela Zeigler for winning a Double Hoo research award! They are working together to perform virtual drug screens for cardiac fibrosis. (link)

January 2016:
Congratulations and farewell to Will Richardson, who is starting his new lab at Clemson!

Article including our high-content imaging in GEN: link

Positions Available:
2 post-doc positions available: http://goo.gl/qNNltB
Graduate students - apply to UVA Biomedical Engineering here and email Dr. Saucerman for more information about specific opportunities.
Undergrad students - email Dr. Saucerman for more information. If you're interested in our lab feel free to come to our lab meetings, Fridays 9-10:15 am in MR5 Room 1019 (the CVRC library).