Heart function and failure are controlled by complex signaling and transcriptional networks that are just beginning to be mapped. Our lab combines computational modeling and high-throughput experiments to discover molecular networks and drugs that control cardiac remodeling and regeneration. Our experimental approaches include high-throughput microscopy and -omic profiling of primary and induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Our computational approaches include large-scale regulatory network modeling and bioinformatic analysis of -omic data. Specific focus areas include:
- cardiomyocyte hypertrophy and death
- extra-cellular matrix remodeling by fibroblasts and macrophages
- cardiomyocyte proliferation
SauceLab on Twitter (link): most updated info here
UVA BME Department news (link)
Post-doc position available on integrating large-scale network models and -omic data on hiPSC-CM cardiotoxicity: (ad)
Post-doc position available co-mentored with Tom Barker to model therapeutic control of fibroblasts/fibrosis by synthetic gene circuits: (ad)
Graduate students - apply to UVA Biomedical Engineering here and email Dr. Saucerman for more information about specific opportunities.
Undergrad students - email Dr. Saucerman for more information. If you're interested in our lab feel free to come to our lab meetings, Fridays 9-10:15 am in MR5 Room 1019 (the CVRC library).
Nice article on Angela and Ani's Double Hoo Award https://t.co/JNzRvg7xmi.
Congratulations to Angela Zeigler and Bryan Chun, who were both awarded NIH F30 Individual Predoctoral MD/PhD Fellowships!
Congratulations on Angela Zeigler, who has received an AHA predoctoral fellowship! Angela also recently published her paper "A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation." in the Journal of Molecular and Cellular Cardiology (link)
Congrats to Ani Chandrabhatla and Angela Zeigler for winning a Double Hoo research award! They are working together to perform virtual drug screens for cardiac fibrosis. (link)
Congratulations and farewell to Will Richardson, who is starting his new lab at Clemson!
Article including our high-content imaging in GEN: link