Heart function and failure are controlled by complex signaling and gene-regulatory networks that are just beginning to be mapped. Our lab combines computational modeling and high-throughput experiments to discover molecular networks and drugs that control cardiac remodeling and regeneration. Our experimental approaches include high-throughput microscopy and -omic profiling of primary and induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Our computational approaches include large-scale regulatory network modeling and bioinformatic analysis of -omic data. Specific focus areas include:

  • cardiomyocyte hypertrophy and death
  • extra-cellular matrix remodeling by fibroblasts and macrophages
  • cardiomyocyte proliferation

News:
SauceLab news on Twitter (link)
UVA BME Department news (link)

Positions Available:
Graduate students - apply to UVA Biomedical Engineering here and email Dr. Saucerman for more information about specific opportunities.

Post-doc applicants: email Dr. Saucerman for more information about specific opportunities. We have openings for both computational and experimental projects.

Post-bac or Lab Specialist positions: Apply at https://jobs.virginia.edu to posting #0620626 and email Dr. Saucerman. We have openings for both computational and experimental projects.

Undergrad students - email Dr. Saucerman for more information.

If you're interested in our lab feel free to come to our lab meetings, Fridays 9-10:15 am in MR5 Room 1019 (the CVRC library).