Heart function and failure are controlled by complex signaling and transcriptional networks that are just beginning to be mapped. Our lab combines computational modeling and high-throughput experiments to discover molecular networks and drugs that control cardiac remodeling and regeneration. Our experimental approaches include high-throughput microscopy and -omic profiling of primary and induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Our computational approaches include large-scale regulatory network modeling and bioinformatic analysis of -omic data. Specific focus areas include:

  • cardiomyocyte hypertrophy and death
  • extra-cellular matrix remodeling by fibroblasts and macrophages
  • cardiomyocyte proliferation

News:
SauceLab on Twitter (link): most updated info here
UVA BME Department news (link)

Positions Available:
Post-doc position available on integrating large-scale network models and -omic data on hiPSC-CM cardiotoxicity: (ad)
Post-doc position available co-mentored with Tom Barker to model therapeutic control of fibroblasts/fibrosis by synthetic gene circuits: (ad)
Graduate students - apply to UVA Biomedical Engineering here and email Dr. Saucerman for more information about specific opportunities.
Undergrad students - email Dr. Saucerman for more information. If you're interested in our lab feel free to come to our lab meetings, Fridays 9-10:15 am in MR5 Room 1019 (the CVRC library).

October 2016:
Nice article on Angela and Ani's Double Hoo Award https://t.co/JNzRvg7xmi.

September 2016:
Congratulations to Angela Zeigler and Bryan Chun, who were both awarded NIH F30 Individual Predoctoral MD/PhD Fellowships!

May 2016:
Congratulations on Angela Zeigler, who has received an AHA predoctoral fellowship! Angela also recently published her paper "A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation." in the Journal of Molecular and Cellular Cardiology (link)

April 2016:
Congrats to Ani Chandrabhatla and Angela Zeigler for winning a Double Hoo research award! They are working together to perform virtual drug screens for cardiac fibrosis. (link)

January 2016:
Congratulations and farewell to Will Richardson, who is starting his new lab at Clemson!

Article including our high-content imaging in GEN: link