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Cell signaling networks coordinate a wide variety of cellular physiology and gene regulatory programs. Perturbations in these signaling networks contribute to the pathogenesis of many diseases, including cardiovascular disease, cancer and diabetes. One explanation for the remarkable ability of complex signaling networks to control the cell is the use of temporal and spatial strategies, such as feedback and compartmentation. Understanding of these sophisticated control mechanisms will require an integration of experimental and computational systems biology.
News and Announcements:
August 2008: Congratulations to Dr. Jeff Saucerman for acceptance of his paper entitled "Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes" in Biophysical J.
July 2008: Dr. Jeff Saucerman presents at the Gordon Research Conference 2008: Cardiac Regulatory Mechanisms.
June 2008: Dr. Jeff Saucerman presents at The 2nd International Symposium on Bio- and Medical Informatics and Cybernetics: BMIC 2008.
May 2008: Congratulations to Jason Yang for passing his Comprehensive Exam!
Congratulations to Ryan Connolly and Sean Meredith on their graduation!
April 2008: Dr. Jeff Saucerman presents at Experimental Biology 2008.
March 2008: CSBL awarded a UVA-Coulter Foundation Translational Research Grant to collaborate with Dr. Randall Moorman (UVA, Cardiovascular Medicine) and Dr. Karen Fairchild (UVA, Pediatrics) on developing improved diagnostic models for neonatal sepsis.
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Positions Available:
Graduate/Undergraduate Students - Modeling and live-cell imaging of cardiac signaling networks - apply to UVA Biomedical Engineering here and email Dr. Jeff Saucerman for more information about specific opportunities.