Cancer is a disease of misregulated genes, proteins, metabolites, cells, and biophysical forces. Early-stage cancers are difficult to diagnose and characterize, and late-stage cancers are invariably hard to treat. Clinically, cancer is an enormous burden on human health and society. The challenges span multiple spatiotemporal scales and will require engineering approaches to solve.
The Biomedical Engineering faculty at UVA have established a multi-pronged effort aimed at cancer biology, cancer imaging, and cancer therapy. Tissue foci include cancers of the breast, brain, pancreas, lung, and kidney. Many of the faculty have strong connections with the NCI-designated Cancer Center, which is also located in the heart of the UVA Health System.
Song Hu: multi-parametric microscopy of the tumor microenvironment in vivo
Kevin Janes: intratumor regulatory heterogeneities and cancer systems biology methods
Kimberly Kelly: biomarker discovery, molecular imaging and targeted therapy
Jenny Munson: tissue engineered cancer models to probe the tumor microenvironment
Jason Papin: network analysis of cancer metabolism
Richard Price: image-guided delivery of therapeutic drug- and gene-bearing nanoparticles to brain tumors
Sasha Klibanov: targeted/molecular ultrasound imaging of tumor neovasculature biomarkers; image guided drug delivery and focused ultrasound tumor therapy
Mark Williams: development of molecular and multi-modality imaging systems, especially for breast cancer