Ph.D., Bioengineering, University of California, San Diego, 2005

Department of Biomedical Engineering
University of Virginia
Box 800759 Health System
Charlottesville, VA 22908

jsaucerman@virginia.edu

Laboratory web site

Research Interests

Heart function and disease are controlled by complex molecular networks that are just beginning to be mapped out. Our lab develops mathematical models to understand how these molecular control systems work, and then we perform a variety of experiments to test this understanding. Experimental techniques include cell culture, live-cell fluorescence imaging, and biochemical assays. These integrated approaches are helping us harness molecular networks to reverse the progression of heart disease.

Current Projects
1) Beta-adrenergic signaling and novel therapies in heart failure
2) Live-cell imaging of cAMP compartmentation
3) Multi-scale modeling of signaling networks
4) Calcium signaling pathways regulating heart contractility and growth
5) Diagnosis of neonatal sepsis by its actions on the heart

Recent Publications

Fairchild KD, Saucerman JJ, Raynor LL, Sivak JA, Xiao Y, Lake DE, Moorman JR
Endotoxin depresses heart rate variability in mice: Cytokine and steroid effects.

Song Q, Saucerman JJ, Bossuyt J, Bers DM
Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.

Saucerman JJ, Bers DM
Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes.

Saucerman JJ, McCulloch AD
Cardiac beta-adrenergic signaling: from subcellular microdomains to heart failure.

Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes.

More Publications