Michael Salerno Michael Salerno, MD, PhD

Assistant Professor of Medicine (Cardiology), Radiology, and Biomedical Engineering

BS, Biological Engineering, Cornell University, 1996
PhD, Biomedical Engineering, University of Virginia, 2001
MD, University of Virginia, 2003
Internal Medicine Residency, Stanford University
Cardiology Fellowship, Duke University
Advanced Cardiovascular Imaging Fellowship, University of Virginia

Office: MR4 Room 1190
Phone: 434-982-6135

Research Interests

Our laboratory’s research involves the development and evaluation of novel magnetic resonance imaging (MRI) pulse sequences and techniques to improve the clinical utility of cardiovascular MRI (CMR). Our lab is an interdisciplinary group which includes undergraduate and graduate engineering students as well as clinical cardiologists and cardiovascular imaging fellows with the goal of bringing new advances into clinical practice. From an engineering perspective we are actively involved in the design and implementation of MRI pulse sequences and the development of new advanced image reconstruction and image processing techniques. The current clinical focus of the research is on myocardial perfusion imaging, imaging of myocardial fibrosis and multi-parametric imaging of ventricular remodeling following myocardial infarction. Students in the laboratory benefit from having the opportunity to directly apply new imaging techniques in human subjects, and to work along with physicians to create robust clinically relevant techniques. We also collaborate very closely with other investigators in BME and Cardiology including Dr. Frederick Epstein, Dr. Craig Meyer, Dr. Christopher Kramer and Dr. Kenneth Bilchick.

Current Projects

  1. Developing improved techniques for whole-heart quantitative assessment of perfusion using spiral k-space pulse sequences and parallel imaging and compressed sensing reconstruction techniques. We are developing robust techniques for adenosine first-pass perfusion stress testing to improve diagnosis of coronary artery disease and to characterize microvascular disease.

  2. Developing and applying T1 mapping techniques to assess diffuse myocardial fibrosis and optimizing strain imaging techniques to assess myocardial function in patients with heart failure with preserved EF (HF-PEF). The goal is to improve the diagnosis of HF-PEF and to guide the development of novel therapies for this disease.

  3. Study myocardial infarct remodeling in a closed-chest porcine model of myocardial infarction. This project utilizes advanced CMR techniques to quantitative characterize the remodeling process with the goal of developing novel therapies to prevent adverse cardiac remodeling and heart failure following myocardial infarction.

  4. Apply T1 mapping and advanced strain imaging techniques to characterize inflammation, scarring and myocardial function in chemotherapy induced cardiotoxicity.

Recent Publications

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