Our research focuses on inventing, developing and applying new
magnetic resonance imaging (MRI) techniques, especially techniques
that acquire the image data very rapidly. This work involves MRI
physics, signal processing, and image reconstruction techniques. Rapid
MRI acquisition is particularly important for pediatric and cardiac studies,
because of cardiac, respiratory, and voluntary motion.
Real-time MRI is essential for guiding therapy, and is also valuable
for cardiac and lung imaging.
One focus of our research is imaging atherosclerosis in arteries and its
effects on perfusion of the heart, brain, and legs.
An essential element of our research is continual collaboration with
other academic labs. Continual collaboration with clinical researchers enables
us to understand clinical needs, and these collaborators can then determine the value
of the resulting techniques in medical practice.
In much of our research,
we also work with industrial collaborators with the goal of making our techniques widely
Improving the efficacy, safety, and efficiency of MR-guided focused ultrasound neurosurgery by
providing comprehensive MRI feedback to the surgeon. This will enable improved minimally
invasive surgery for movement disorders such as essential tremor and Parkinson’s disease.
Translating rapid spiral MRI methods for body and brain imaging to commercial application.
Eliminating the need for sedation for young children during MRI scans using advanced rapid
imaging methods and correction for patient motion.
Developing rapid and robust methods for dynamic non-contrast perfusion imaging of stroke and brain tumor patients.
Developing spiral k-space scanning techniques to image myocardial perfusion in patients with
myocardial ischemia and microvascular disease.
Studying peripheral arterial disease using a comprehensive collection of MRI methods, including vessel wall
imaging, non-contrast angiography and perfusion measurements.
Developing methods for rapidly imaging the muscles of the lower extremity to provide input data
for musculoskeletal modeling of athletes and of patients with musculoskeletal disorders.
Developing methods for molecular and cellular imaging of cardiovascular inflammation using fluorine MRI methods.
Improving the efficiency and reliability of high-resolution MR coronary artery imaging.
Increasing the frame rate and image quality of real-time MRI through novel data acquisition and
image reconstruction techniques.
Developing rapid methods of imaging the lung using hyperpolarized gas to image children and adults with
Applying spiral imaging methods to characterize heart failure quantitatively.