Our research focuses on inventing, developing and applying new
magnetic resonance imaging (MRI) techniques, especially techniques
that acquire the image data very rapidly. This work involves MRI
physics, signal processing, and image reconstruction techniques. Rapid
MRI acquisition is particularly important for cardiac studies, because
of cardiac and respiratory motion. One focus of our research is
imaging atherosclerosis in arteries and its effects on perfusion of
the heart, brain, and legs. In much of our research, we work with
industrial collaborators with the goal of making our techniques widely
We collaborate with other labs at the University of Virginia on a
variety of projects. One such collaboration is focused on developing
new contrast agents and imaging methods for molecular and cellular
imaging of cardiovascular inflammation. Another collaboration is
focused on developing image-based models of musculoskeletal
disease. We are also studying peripheral arterial disease through a
set of MRI methods and developing new methods of characterizing heart
failure. In collaboration with the hyperpolarized-gas MRI group, we
are developing fast methods of imaging the lung.
Improving the efficiency and reliability of high-resolution MR coronary artery imaging.
Developing rapid and robust methods for dynamic non-contrast perfusion imaging of
stroke and brain tumor patients.
Improving the speed and accuracy of MR-guided focused ultrasound surgery by developing
new methods for rapid 3D MR temperature mapping.
Developing methods for molecular and cellular imaging of cardiovascular inflammation using
multinuclear MRI methods.
Developing spiral k-space scanning techniques to image myocardial perfusion
in patients with myocardial ischemia and microvascular disease.
Developing methods for rapidly imaging the muscles of the lower
extremity to provide input data for musculoskeletal modeling of
athletes and of patients with musculoskeletal disorders.
Increasing the frame rate and image quality of real-time MRI of the heart and soft palate
through novel data acquisition and image reconstruction techniques.
Applying our spiral imaging methods to characterize heart failure quantitatively.
Studying peripheral arterial disease using a comprehensive
collection of MRI methods, including vessel wall imaging,
non-contrast angiography and perfusion measurements.
Developing rapid methods of imaging the lung using hyperpolarized gas to image children and adults
with lung disease.