The Lampe Group’s research interests are in the areas of the following:
- Neural tissue engineering
- Drug delivery
- Redox regulation of stem cell fate
- Engineering cell-interactive microenvironments
Neural regeneration within the central nervous system (CNS) is a critical unmet challenge as CNS disorders continue to be the leading cause of disability nationwide. Many novel drug delivery and 3-dimensional tissue engineering strategies present innovative therapeutic approaches, but still require substantial research into cell-biomaterial interactions before they can be effectively translated to the clinic. Engineers can provide a unique perspective in the design and development of materials for human health.
Our research is an innovative combination of in vitro systems and future in vivo applications of biomaterial-stem cell interactions drawing on aspects of engineering, stem cell biology, and neuroscience with a unifying theme of functional neural tissue engineering. Our overarching goal is to develop a new, integrated approach in building material systems that are both cell-instructive and cell-responsive, creating a dynamic feedback loop between a cell and its engineered microenvironment.
Our multidisciplinary lab focuses on biomaterial and drug delivery applications for neurodegenerative diseases and injuries of the CNS and investigate material effects on cell behaviors such as proliferation, differentiation, directed neurite growth, and tissue function.
- Interactive 3D culture materials that support neuron maturation and axon myelination
- Tailored drug delivery within the central nervous system via passive and active mechanisms
- Redox regulation of stem cell self-renewal and differentiation
KJ Lampe, AL Antaris, SC Heilshorn "Design of 3D engineered protein hydrogels for tailored control of neurite growth," Acta Biomaterialia, 9: 5590-5599 (2013) (link).
C Chung, KJ Lampe, SC Heilshorn "Tetrakis (hydroxyl methyl) phosphonium chloride as a covalent crosslinking agent for cell encapsulation within protein-based hydrogels," Biomacromolecules, 13: 3912-3916 (2012) (link).
KJ Lampe, SC Heilshorn "Building stem cell niches from the molecule up through engineered peptide materials," Neuroscience Letters, 519: 138-146 (2012) (link).
BA Aguado, W Mulyasasmita, J Su, KJ Lampe, SC Heilshorn, "Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers," Tissue Engineering Part A, 18: 806-815 (2012) (link).
KJ Lampe, DS Kern, MJ Mahoney, KB Bjugstad, "The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: protein distribution and the glial response," Journal of Biomedical Materials Research Part A, 96A: 595-607 (2011) (link).
KJ Lampe, RG Mooney, KB Bjugstad, MJ Mahoney, "Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture," Journal of Biomedical Materials Research Part A: 94A, 1162-1171 (2010) (link).
KJ Lampe, KB Bjugstad, MJ Mahoney, "Impact of degradable macromer content in a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and differentiation," Tissue Engineering Part A, 16:1857-1866 (2010) (link).
KB Bjugstad, DE Redmond, KJ Lampe, DS Kern, JR Sladek Jr, MJ Mahoney, "Biocompatibility of PEG-Based Hydrogels in Primate Brain," Cell Transplantation, 17:409-417 (2008) (link).