Changes in cellular behavior underlie development, disease, and tissue homeostasis. The response of cells to external factors depends upon posttranslational signals and changes in gene expression. These biomolecules are wired together in cells to form networks. Intracellular signaling and gene-expression networks are highly interconnected and time dependent, making them difficult to study and even harder to understand at the systems level.
Our lab designs new experimental and computational approaches for analyzing such networks. We draw from engineering principles to inspire new techniques that can be applied to network-level questions about signal transduction and gene expression. We are particularly interested in using our methods for problems in cancer biology, where the molecular “signal processing” has gone awry and cellular responses are inappropriate.