Song Hu

Song Hu

Assistant Professor of Biomedical Engineering

Ralph E. Powe Junior Faculty Enhancement Award

Ph.D., Biomedical Engineering, Washington University in St. Louis, 2010
B.S. and M.S. Tsinghua University, Beijing, 2002 and 2005

Dept. of Biomedical Engineering
UVA Health System
PO Box 800759
Charlottesville, VA 22908

Office: Room 2115 Phone:434-924-9950
Lab: Room 2215 Phone:434 924-9951 and 434 924-1640


songhu@virginia.edu

Laboratory web site

Google Scholar Profile

   

Research Interests

My academic interest is combining optics and ultrasound for in vivo high-resolution imaging of anatomical, functional, metabolic, molecular, and genetic contrasts at multiple spatial and temporal scales. This research effort encompasses three aspects: revealing new optical contrast mechanisms for enhanced imaging sensitivity and specificity, ultrasonically bridging the spatial gaps between microscopic laboratory research and macroscopic clinical practice, and pushing the technical envelope to cover temporal scales that range from fast hemodynamics to chronic developmental and aging processes. Our group will focus on both life science applications and clinical translation.

Current Research

My current research focuses on photoacoustic microscopy (PAM), a fast-growing modality complementing existing microscopy techniques with rich physiological contrasts based on optical absorption and broad spatial scalability based on ultrasonic detection. Optical-resolution PAM (OR-PAM), which I have developed with my colleagues, refines the spatial scale of traditional photoacoustic imaging from organ to cell level in vivo, and spans a temporal scale from microseconds to a lifetime. In the few years since its invention in 2007, OR-PAM has found broad applications in neurology, vascular biology, oncology, dermatology, ophthalmology, developmental biology, cardiology, and tissue engineering.

Selected Publications

(† equal contribution)

1. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458-1462 (2012).

2. S. Oladipupo†, S. Hu†, J. Kovalski, J. Yao, A. C. Santeford, R. Sohn, R. V. Shohet, K. Maslov, L. V. Wang, and J. M. Arbeit, “VEGF is essential for hypoxia-inducible factor mediated neovascularization but dispensable for endothelial sprouting,” Proceedings of the National Academy of Sciences 108(32), 13264-13269 (2011).

3. H.-W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J.-X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Physical Review Letters 106(23), 238106 (2011). (Featured by Science)

4. S. Oladipupo†, S. Hu†, A. C. Santeford, J. Yao, J. Kovalski, R. V. Shohet, K. Maslov, L. V. Wang, and J. M. Arbeit, “Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence," Blood 117(15), 4142-4153 (2011).

5. S. Hu†, K. Maslov†, and L. V. Wang, "Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed," Optics Letters 36(7), 1134–1136 (2011). (Featured article)

6. S. Hu and L. V. Wang, "Neurovascular photoacoustic tomography," Frontiers in Neuroenergetics 2(10), doi:10.3389/fnene.2010.00010 (2010).

7. S. Hu and L. V. Wang, "Photoacoustic imaging and characterization of the microvasculature," Journal of Biomedical Optics 15(1), 011101 (2010). (4th most cited article in Journal of Biomedical Optics since 2009)

8. S. Hu, B. Rao, K. Maslov, and L. V. Wang, "Label-free photoacoustic ophthalmic angiography," Optics Letters 35(1), 1–3 (2010). (Featured by Virtual Journal of Biomedical Optics)

9. S. Hu, K. Maslov, V. Tsytsarev, and L. V. Wang, "Functional transcranial brain imaging by optical-resolution photoacoustic microscopy," Journal of Biomedical Optics 14(4), 040503 (2009). (6th most cited article in Journal of Biomedical Optics since 2009)

10. S. Hu, K. Maslov, and L. V. Wang, "Noninvasive label-free imaging of microhemodynamics by optical-resolution photoacoustic microscopy," Optics Express 17(9), 7688-7693 (2009).

11. K. Maslov†, H. F. Zhang†, S. Hu†, and L. V. Wang, "Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries," Optics Letters 33(9), 929–931 (2008). (5th most cited article in Optics Letters since 2007)