George T. Gillies George T. Gillies

Research Professor of Mechanical and Biomedical Engineering
Clinical Associate Professor of Neurosurgery Medical College of Virginia

B.Sc., North Dakota State University, 1974
M.Sc., University of Virginia, 1976
Ph.D., Engineering Physics, University of Virginia, 1980

Mechanical Aerospace and Nuclear Engineering
J. W. Beams Laboratory of Physics
Room 106 Mc Cormick Road
University of Virginia
Charlottesville, VA 22901



Research Interests

Our research centers on the development of magnetic stereotaxis and medical magnetic manipulation systems for use in neurosurgical, neuroradiological, and other clinical applications. Magnetic stereotaxis is a technique for using magnetic fields and gradients outside the patient’s head as a means of navigating an implanted device such as a drug delivery catheter or an intracerebrovascular probe for thrombosing aneurysms. An important part of this effort is the design and prototyping of novel neurosurgical instruments and technologies used in conjunction with magnetic stereotaxis or in related surgical procedures. Other research includes studies of spinal mechanics and the kinematics of the suboccipital region of the craniomandibular complex, the development of stem cell-based techniques for the treatment of Parkinson’s disease, and the development of antisense gene therapy strategies for neoplastic diseases of the central nervous system.

Selected Publications

M. A. Howard, III, B. A. Abkes, M. C. Ollendieck, M. D. Noh, R. C. Ritter, and G. T. Gillies. Measurement of the force required to move a neurosurgical probe through in vivo human brain tissue. IEEE Transactions in Biomedical Engineering, 46:891-894, 1999.

H. L. Fillmore, J. Shurm, P. Furqueron, S. S. Prabhu, G. T. Gillies, and W. C. Broaddus. An in vivo rat model for visualizing glioma tumor cell invasion using stable persistent expression of the green fluorescent protein. Cancer Letters, 141:9-19, 1999.

W. C. Broaddus, Y. Liu, L. L. Steele, G. T. Gillies, P.-S. Lin, W. G. Loudon, C. K. Valerie, R. K. Schmidt-Ulrich, and H. L. Fillmore. Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transduction. Journal of Neurosurgery, 91: 997-1004, 1999.