Bradley Gelfand Bradley Gelfand, PhD
Assistant Professor of Opthamology


B.S.E. University of Iowa, 2004
Ph.D., Biomedical Engineering, University of Virginia, 2010

Center for Advanced Vision Science
415 Lane Road
Charlottesville, VA 22908

Office: 3133 MR-5 Phone: 434-924-7886

gelfand@virginia.edu
Website

   

Research Interests

The Gelfand Laboratory investigates various aspects of the blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.

One major focus of our work is to study the cellular and molecular consequences of the blood supply in the eye. Specifically, we are interested in quantifying the biomechanical changes that occur in the choroidal vasculature in healthy and diseased eyes, and how these micro-environmental cues affect the biology and pathology of the eye. To accomplish this, we perform high-resolution 3-D microscopy to generate accurate maps of the human choroidal anatomy in health and in disease which is utilized for computational fluid dynamic modeling. To study the influence of choroidal hemodynamics on ocular health, we employ a sophisticated cell culture system which is capable of reproducing the hemodynamic environment of the human eye.

In a related project, our research analyzes the molecular mechanisms which underlie development of age-related macular degeneration. One such pathway involves deficiency of the RNA processing enzyme DICER1. Specifically, we seek to determine how DICER1 deficiency promotes death of retinal cells and the consequences of DICER1 deficiency on aberrant blood vessel growth.

Selected Publications

A Revised Hemodynamic Theory of Age-Related Macular Degeneration.
Gelfand BD, Ambati J.
Trends in Molecular Medicine 2016 Aug;22(8):656-70. Epub 2016 Jul 13. Review. PMID: 27423265

Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.
Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Núñez G, Georgel P, Dunaief JL, Ambati J.
Cell Reports. 2015 Jun 23;11(11):1686-93. PMID: 26074074

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J.
Science. 2014 Nov 21;346(6212):1000-3. PMID: 25414314