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Mark B. Williams

Associate Professor of Radiology, Physics, and Biomedical Engineering

B.S., Physics, Grinnell College, 1977
M.S., Physics, Wake Forest University, 1983
Ph.D., Physics, University of Virginia, 1990
Complete CV

University of Virginia Department of Radiology
Box 170
Charlottesville, VA 22908

mbwilliams@virginia.edu

Research Interests

The general area of research in my lab is the design, development, and optimization of medical imaging technologies. The following projects are underway:

1) Dual modality breast imaging: We are developing an integrated imaging system that combines the sensitivity of digital mammography with the specificity of scintimammography in a single compact, upright unit. The imaging system functions by obtaining mirror-image x-ray transmission and gamma emission images concurrently with the breast in a single configuration. Co-registration then correlates the gamma and x-ray images to within a fraction of a pixel.

2) Molecular imaging system for small animal research: We are developing a tomographic imaging system that permits simultaneous acquisition of high resolution functional (SPECT) and structural (x-ray CT) images from mice and rats. The resulting fused image correlates the radiotracer distribution with the morphological information provided by the x-ray data. A similar 2-dimensional system is being routinely utilized as a component of the Small Animal Multimodality Imaging Center for mouse and rat studies in gene expression imaging, radiation oncology and diagnostic radiology.

3) Evaluation of basic imaging properties of early commercial systems for digital breast imaging. Characteristics being quantified include sensitivity, linearity, spatial resolution, noise properties, and detective quantum efficiency. We are working with a consortium of detector physicists located across North America to develop uniform evaluation methods and to produce a combined data set.

Selected Publications

Williams MB, More MJ, Narayanan D, Majewski S, Welch B, Wojcik R, and Kieper DA. Phantom Study of Radiotracer Concentration Quantification in Breast Scintigraphy. IEEE Transactions on Nuclear Science June 2003; 50(3):433-438.

Williams MB, More MJ, Narayanan D, Majewski S, Weisenberger AG, Wojcik R, Stanton M, Phillips W, and Stewart A. Combined Structural and Functional Imaging of the Breast. Technology in Cancer Research and Treatment 2002; 1:39-42.

Williams MB, Goode AR, Galbis-Reig V, Majewski S, Weisenberger AG, and Wojcik R. Performance of a PSPMT Based Detector for Scintimammography. Phys. Medical Biology 2000; 45(3):781-800.

More MJ, Narayanan D, Goodale PJ, Majewski S, Welch B, Wojcik R, Kieper DA, and Williams MB. X-ray Stereotactic Lesion Localization in Conjunction with Dedicated Scintimammography. IEEE Transactions on Nuclear Science 2003, in press.

Williams MB, Stolin AV, and Kundu BK. Investigation of Spatial Resolution and Efficiency Using Pinholes with Small Pinhole Angle. IEEE Transactions on Nuclear Science 2003, in press.

Williams MB, Narayanan D, More MJ, Goodale PJ, Majewski S, Kieper DA. Analysis of Position-Dependent Compton Scatter in Scintimammography with Mild Compression. IEEE Transactions on Nuclear Science 2003, in press.

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