 |
Assistant Professor of Biomedical Engineering
Ph.D., Bioengineering, University of California, San Diego, 2005
Department of Biomedical Engineering
University of Virginia
Box 800759 Health System
Charlottesville, VA 22908
jsaucerman@virginia.edu
Laboratory web site
|
Research Interests
Heart function and disease are controlled by complex molecular
networks that are just beginning to be mapped out. Our lab develops
mathematical models to understand how these molecular control systems
work, and then we perform a variety of experiments to test this
understanding. Experimental techniques include cell culture, live-cell
fluorescence imaging, and biochemical assays. These integrated
approaches are helping us harness molecular networks to reverse the
progression of heart disease.
Current Projects:
1) Beta-adrenergic signaling and novel therapies in heart failure
2) Live-cell imaging of cAMP compartmentation
3) Multi-scale modeling of signaling networks
4) Calcium signaling pathways regulating heart contractility and growth
5) Diagnosis of neonatal sepsis by its actions on the heart
Selected Publications
Saucerman JJ, Bers DM. "Calmodulin mediates differential sensitivity
of CaMKII and calcineurin to local Ca2+ in cardiac myocytes." Biophys J. 2008 Nov 15;95(10):4597-612.
[Pubmed]
Song Q, Saucerman JJ, Bossuyt J, Bers DM. "Differential integration of Ca-calmodulin signal in intact
ventricular myocytes at low and high affinity Ca-calmodulin targets." J Biol Chem. 2008 Nov 14;283(46):31531-40.
[Pubmed]
Saucerman JJ, McCulloch AD. "Cardiac beta-Adrenergic Signaling: From
Subcellular Microdomains to Heart Failure." Ann N Y Acad Sci. 2006
Oct;1080:348-61.
[Pubmed]
Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY,
McCulloch AD. "Systems analysis of PKA-mediated phosphorylation
gradients in live cardiac myocytes." Proc Natl Acad Sci U S A. 2006
Aug 22;103(34):12923-8.
[Pubmed]
PubMed listings for this faculty member
|
Back to the Faculty Page >> |
