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Jeffrey Saucerman

Jeffrey Saucerman

Assistant Professor of Biomedical Engineering

Ph.D., Bioengineering, University of California, San Diego, 2005

Department of Biomedical Engineering
University of Virginia
Box 800759 Health System
Charlottesville, VA 22908

jsaucerman@virginia.edu

Laboratory web site

Selected Publications

Research Interests

Heart function and disease are controlled by complex molecular networks that are just beginning to be mapped out. Our lab develops mathematical models to understand how these molecular control systems work, and then we perform a variety of experiments to test this understanding. Experimental techniques include cell culture, live-cell fluorescence imaging, and biochemical assays. These integrated approaches are helping us harness molecular networks to reverse the progression of heart disease.

Current Projects:
1) Beta-adrenergic signaling and novel therapies in heart failure
2) Live-cell imaging of cAMP compartmentation
3) Multi-scale modeling of signaling networks
4) Calcium signaling pathways regulating heart contractility and growth
5) Diagnosis of neonatal sepsis by its actions on the heart

Selected Publications

Saucerman JJ, Bers DM. "Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes." Biophys J. 2008 Nov 15;95(10):4597-612. [Pubmed]

Song Q, Saucerman JJ, Bossuyt J, Bers DM. "Differential integration of Ca-calmodulin signal in intact ventricular myocytes at low and high affinity Ca-calmodulin targets." J Biol Chem. 2008 Nov 14;283(46):31531-40. [Pubmed]

Saucerman JJ, McCulloch AD. "Cardiac beta-Adrenergic Signaling: From Subcellular Microdomains to Heart Failure." Ann N Y Acad Sci. 2006 Oct;1080:348-61. [Pubmed]

Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. "Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes." Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12923-8. [Pubmed]

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