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John P. Mugler, III

Professor of Radiology and Biomedical Engineering

B.S., University of Virginia, 1980
M.S., Stanford University, 1981
Ph.D., Biomedical Engineering, University of Virginia, 1988

University of Virginia
Department of Radiology
Box 801339
Charlottesville, VA 22908

jpm7r@virginia.edu

Research Interests

Our research focuses on the development and optimization of magnetic resonance imaging techniques, particularly those for rapid and three-dimensional imaging, drawing on a variety of physics and engineering principles, with a strong emphasis on theoretical modeling and simulation and on practical implementation and evaluation. Currently, our major focuses include high-resolution 3-D imaging of the brain using conventional proton-based methods and imaging and spectroscopy of the lung using hyperpolarized helium- and xenon-based methods. The comprehensive, high-resolution coverage accomplished with the techniques under development for 3-D brain imaging will provide more complete descriptions of pathological components of brain diseases, higher probabilities of detecting focal abnormalities, and more accurate quantitative evaluations of the extent of lesions. Hyperpolarized helium and xenon represent new MR-based contrast agents that are particularly well suited for imaging air spaces such as those in the lungs. This methodology provides high-resolution detailed images of the lungs that are far superior in quality to any existing clinical imaging methods.

Selected Publications

Mata J, Altes T, Cai J, Ruppert K, Mitzner W, Hagspiel KD, Patel B, Salerno M, Brookeman JR, de Lange EE, Tobias WA, Wang HT, Cates GD, Mugler JP III. Evaluation of Emphysema Severity and Progression in a Rabbit Model: A Comparison of Hyperpolarized He-3 and Xe-129 Diffusion MRI with Lung Morphometry. J Appl Physiol. 2006 Nov 16.

Wang C, Miller GW, Altes TA, de Lange EE, Cates GD Jr, Mugler JP III. Time dependence of 3He diffusion in the human lung: measurement in the long-time regime using stimulated echoes. Magn Reson Med. 2006 Aug;56(2):296-309.

Ruppert K, Mata JF, Brookeman JR, Hagspiel KD, Mugler JP III. Exploring lung function with hyperpolarized 129Xe nuclear magnetic resonance. Magn Reson Med 2004; 51:676 -687.

Mugler JP III, Bao S, Mulkern RV, Guttmann CRG, Robertson RL, Jolesz FA, Brookeman JR. Optimized single-slab three-dimensional spin-echo MR imaging of the brain. Radiology 2000; 216:891-899.

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