Research Interests
Targeted delivery of therapeutic and diagnostic imaging agents. Design
of ultrasound contrast materials; attachment of targeting ligands to
contrast materials. Colloid based delivery systems (microbubbles and
liposomes). Long-circulating liposomes and particulates.
Ultrasound imaging is a widespread and inexpensive non-invasive
diagnostic technique. Ultrasound contrast agents offer a flexible
platform that can be used for diagnostic imaging as a blood pool
marker (tissue perfusion), as a targeted marker for imaging of
inflammation, angiogenesis, and also as adjunct microdevices for
enhanced targeted drug delivery and gene therapy. In diagnostic
imaging, detection of contrast material offers high sensitivity
(individual micron-sized particles can be visualized in vitro and in
vivo by ultrasound medical imaging systems). We prepare and analyze
such ultrasound contrast materials, attach targeting ligands
(antibodies, peptides) and plasmid DNA to their surface for targeting
and ultrasound-enhanced delivery.
Selected Publications
Klibanov AL.
Microbubble contrast agents: targeted ultrasound imaging and
ultrasound-assisted drug-delivery applications.
Invest Radiol. 2006 Mar;41(3):354-62.
Chappell JC, Klibanov AL, Price RJ.
Ultrasound-microbubble-induced neovascularization in mouse skeletal muscle.
Ultrasound Med Biol. 2005 Oct;31(10):1411-22.
Klibanov AL.
Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for
targeted molecular imaging.
Bioconjug Chem. 2005 Jan-Feb;16(1):9-17.
Klibanov AL.
Molecular imaging with targeted ultrasound contrast microbubbles.
Ernst Schering Res Found Workshop. 2005;(49):171-91.
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