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Assistant Professor of Orthopaedic Surgery and Biomedical Engineering
Ph.D., Biomedical Engineering, Drexel University, 2005
University of Virginia
Box 800374, Cobb Hall, Rm B053
Charlottesville, VA 22908
yk4t@virginia.edu
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Research Interests
The treatment of musculoskeletal defects, particularly bone
defects, due to trauma, congenital defects, or other anomalies is
dominated by the use of autografts and allografts. Autografts are
tissue that is harvested from a donor site within a patient and
re-implanted at the defect site. Allografts are tissue harvested from
a cadaver. Each solution, however, has limitations and presents a
need for suitable alternatives.
Our research interests lie in finding solutions to these problems
through tissue engineering. The development of biocompatible and
biodegradable scaffolds capable of sustaining cellular migration,
proliferation, and differentiation is central to my work. Through the
use of biodegradable polymers alone and in combination with ceramic
materials, we are investigating strategies to synthesize scaffolds
that are also capable of delivering proteins and growth factors
essential for complete and adequate healing of bone defects. Specific
work includes design and synthesis of novel scaffold structures
capable of sustaining substantial mechanical loading while having a
3-dimensional structure conducive to substantial cellular migration
throughout the structure interior. Scaffolds are evaluated through
extensive physical, chemical, and mechanical testing, cell viability
and protein expression, and finally with in vivo bone defect models
that test the overall healing potential of the constructs.
Other laboratory interests include development of bioactive polymeric
surfaces to encourage bone ingrowth and bone-implant interface
strength. Studies in this area included the chemical modification of
polymeric surfaces and the incorporation of ion-donor ceramics, both
of which initiate a calcium phosphate deposition on the surface of
materials, ultimately leading to enhanced healing and bone formation.
Selected Publications
Khan Y, Katti DS, Laurencin CT. A Novel Polymer-Synthesized Ceramic
Composite Based System for Bone Repair: An In Vitro
Evaluation. J. Biomed Mater Res. 69A, 728-737, 2004.
Khan Y, Katti DS, Laurencin CT. A Novel Polymer-Synthesized Ceramic
Composite Based System for Bone Repair: Osteoblast Growth on Scaffolds
With Varied Calcium Phosphate Content. Nanoscale Materials Science in
Biology and Medicine. Editors: C.T. Laurencin, E. Botchwey MRS
Proceedings Volume 845.
Borden MD, Attawia MA, Khan Y, El-Amin SF, Laurencin CT. Tissue
Engineered Bone Formation In Vivo Using a Novel Sintered Polymeric
Microsphere Matrix. J Bone Joint Surg. 86-B(8), 1200-1208, 2004
Laurencin C, Khan Y, El-Amin SF. Bone graft substitutes. Expert Rev Med Devices. 3(1):49-57, 2006.
PubMed listings for this faculty member
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