Frederick Epstein
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Associate Professor of Biomedical Eng. and Radiology
BS, Physics, University of Rochester, 1988
MS, Engineering Physics, University of Virginia, 1990
PhD, Biomedical Engineering, University of Virginia, 1993
Post-doc, Radiology, University of Virginia, 1994
Box 800759
University of Virginia
Charlottesville, VA 22908
fhe6b@virginia.edu |
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Research Interests
The general goal of my lab is to develop MRI techniques for assessing the structure,
function, and perfusion of the cardiovascular system, particularly in the setting
of coronary heart disease. Recent projects have included developing echo-planar
MRI methods for imaging myocardial perfusion throughout the entire heart and
developing displacement-encoded MRI for high-resolution measurements of intramyocardial
motion. We have access to state-of-the-art whole body 1.5T scanners for human
imaging studies and to a high-field 4.7T MRI scanner for imaging small animals,
particularly mice. Through collaborations with cardiologists and molecular biologists,
our novel MRI methods are applied to studies involving both clinical cardiology
and basic cardiovascular science.
Current Projects:
- Echo-planar myocardial tagging for dobutamine stress MRI
- High-resolution myocardial motion tracking using cine displacement-encoded
cardiac MRI
- MRI of myocardial function in post-infarct knockout mice.
Selected Publications
Helm PA, Caravan P, French BA, Jacques V, Shen L, Xu Y, Beyers RJ, Roy
RJ, Kramer CM, Epstein FH.
Postinfarction myocardial scarring in mice:
molecular MR imaging with use of a collagen-targeting contrast
agent.
Radiology. 2008 Jun;247(3):788-96.
Vandsburger MH, French BA, Helm PA, Roy RJ, Kramer CM, Young AA,
Epstein FH.
Multi-parameter in vivo cardiac magnetic resonance imaging
demonstrates normal perfusion reserve despite severely attenuated
beta-adrenergic functional response in neuronal nitric oxide synthase
knockout mice.
Eur Heart J. 2007 Nov;28(22):2792-8.
Spottiswoode BS, Zhong X, Hess AT, Kramer CM, Meintjes EM, Mayosi BM,
Epstein FH.
Tracking myocardial motion from cine DENSE images using
spatiotemporal phase unwrapping and temporal fitting.
IEEE Trans Med
Imaging. 2007 Jan;26(1):15-30.
Kim D, Gilson WD, Kramer CM, Epstein FH.
Myocardial tissue tracking
with two-dimensional cine displacement-encoded MR imaging: development
and initial evaluation.
Radiology. 2004 Mar;230(3):862-71.
PubMed listings for this faculty member
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