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Professor of Molecular Physiology and Biophysical Science and Biomedical
Engineering
Robert M. Berne Professor of Cardiovascular Research
A.B., Biology, University of Colorado, Boulder, Colorado, 1962
Ph.D., Physiology, University of Iowa, Iowa City, Iowa, 1967
brd@virginia.edu |
Research Interests
Our interests focus on cell-cell communication in the vessel wall, especially
the chemical, electrical, and mechanical processes which lead to coordinated
function of endothelial and smooth muscle cells.
We are also interested in local control of blood flow and the ways in which
tissue metabolites match cellular metabolic needs and vascular function. This
interest leads to a set of investigations designed to elucidate the factors
that determine the distribution of red cells in capillaries. In order to study
these problems, we use a variety of optical, electrical, and immunohistological
approaches, including intracellular recording, fluorescent dye measurement of
calcium, and membrane potential studies, both in vitro and in vivo. Techniques
we use include intravital microscopy; cannulated microvessel PO2 measurements;
Ca++ and voltage-sensitive dyes; and capillary rheology.
Selected Publications
Isakson BE, Ramos SI, Duling BR. Ca2+ and inositol 1,4,5-trisphosphate mediated signaling across the
myoendothelial junction. Circ Res. 2007 Feb 2;100(2):246-54.
Isakson BE, Kronke G, Kadl A, Leitinger N, Duling BR.
Oxidized phospholipids alter vascular connexin expression, phosphorylation, and
heterocellular communication.
Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2216-21.
Rubio-Gayosso I, Platts SH, Duling BR.
Reactive oxygen species mediate modification of glycocalyx during
ischemia-reperfusion injury.
Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2247-56.
Isakson BE, Duling BR.
Heterocellular contact at the myoendothelial junction influences gap junction
organization.
Circ Res. 2005 Jul 8;97(1):44-51.
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