Frederick Epstein

Frederick Epstein

Professor and Chair of Biomedical Engineering
Professor of Radiology

Fellow of the ISMRM, Fellow of the American Heart Association, and Fellow of AIMBE

BS, Physics, University of Rochester, 1988
MS, Engineering Physics, University of Virginia, 1990
PhD, Biomedical Engineering, University of Virginia, 1993
Post-doc, Radiology, University of Virginia, 1994

Box 800759
University of Virginia
Charlottesville, VA 22908

fhe6b@virginia.edu

   

Research Interests

The general goal of my lab is to develop magnetic resonance imaging (MRI) techniques for assessing the structure, function, and perfusion of the cardiovascular system, particularly in the setting of cardiovascular disease. While our focus is on imaging in cardiovascular disease, we also involved in imaging in diabetes and in musculoskeletal disorders. Recent projects have included the development of displacement-encoded MRI for quantifying tissue motion, first-pass contrast-enhanced MRI and arterial spin labeling for imaging myocardial perfusion, molecular and cellular imaging of collagen and macrophages in myocardial infarction, and manganese-enhanced imaging of pancreatic beta cells. We use state-of-the-art whole body 1.5T and 3T scanners for human imaging and a high-field 7T MRI scanner for imaging small animals, particularly mice. Through collaborations with radiologists, cardiologists, endocrinologists, molecular biologists, and mechanical and electrical engineers, the novel MRI methods developed by our group are applied in both clinical and basic medical research.


Current Projects

Imaging myocardial mechanics with Cine DENSE (Displacement Encoding with Stimulated Echoes) MRI, including pulse sequence development and improving image analysis methods.

MRI in mouse models of cardiovascular disease. Some projects include 3D Cine DENSE in mice, MRI of macrophage infiltration in myocardial infarction, using arterial spin labeling and first-pass MRI to quantify myocardial perfusion, T2-weighted imaging of myocardial edema, and 3D phase contrast MRI of aortic blood flow and wall shear stress.

MRI of pancreatic beta cells using manganese and other targeted contrast agents as well as quantitation through MR relaxometry and multi-compartment models.

Recent Publications

More Publications