George J. Christ, Ph.D.
Professor of Biomedical Engineering and Orthopaedic Surgery
Mary Muilenburg Stamp Professor of Orthopaedic Research
Director of Basic and Translational Research in Orthopaedic Surgery
Head, Laboratory of Regenerative Therapeutics
Fellow of AIMBE
Ph.D., Wake Forest University, 1987
Charlottesville, VA 22908
||Room 1131, 1137
The Laboratory of Regenerative Therapeutics at the University of Virginia is an interdisciplinary, translational research enterprise. Our mission is to leverage Cross Grounds collaborations to develop novel and more efficacious regenerative medicine/tissue engineering technologies for unmet medical needs. Our collaborative team has expertise ranging from the genetic to the molecular, cellular, tissue and organs levels, including development of biologically relevant preclinical animal models and experience with IND submission for gene transfer and tissue engineering technologies. While we have broad interest and experience in striated and smooth muscle physiology and pharmacology, our major current focus is on musculoskeletal tissue engineering and regeneration. In particular, we are developing a technology platform for the treatment of volumetric muscle loss (VML) injuries. We also endeavor to develop new biomaterials for enhanced muscle regeneration and neural. Our translational research efforts are enhanced by our close integration/interaction with clinicians, most notably, the Dept. of Orthopaedic Surgery. Please see our lab website, www.christlab.org, for descriptions of our group's current projects.
Neff LP, Tillman BW, Yazdani SK, Machingal MA, Yoo JJ, Soker S, Bernish BW, Geary RL, Christ GJ. Vascular smooth muscle enhances functionality of tissue-engineered blood vessels in vivo. J Vasc Surg. 2011 Feb;53(2):426-34.
Machingal MA, Corona BT, Walters TJ, Kesireddy V, Koval CN, Dannahower A, Zhao W, Yoo J and Christ GJ: A tissue engineered muscle repair (TE-MR) construct for functional restoration of an irrecoverable muscle injury in a murine model. Tissue Eng Part A 2011
Corona BT, Machingal MA, Criswell T, Vadhavkar M, Dannahower A, Bergman C, Zhao W, Christ GJ: Further development of a tissue engineered muscle repair (TEMR) construct in vitro for enhanced functional recovery following implantation in vivo in a murine model of volumetric muscle loss (VML) injury. Tissue Eng Part A. Jun;18(11-12):1213-28. doi: 10.1089/ten.TEA.2011.0614. Epub 2012 May 10.
Christ GJ, Saul JM, Furth ME, Andersson KE: The Pharmacology of Regenerative Medicine. Pharmacol Rev. 2013 Jul 1;65(3):1091-133. doi: 10.1124/pr.112.007393. Print 2013. PMID: 23818131 [PubMed - in process].
Ward C, Corona B, Harrison B, Yoo JL and Christ GJ: Oxygen generating biomaterials preserve skeletal muscle homeostasis under hypoxic and ischemic conditions. PloS One (Accepted), 2013.
Corona BT, Ward CL, Baker HB, Walters TJ, Christ GJ. Implantation of in vitro tissue engineered muscle repair (TEMR) constructs and bladder acellular matrices (BAM) partially restore in vivo skeletal muscle function in a rat model of volumetric muscle loss (VML) injury. Tissue Eng Part A. 2013 Sep 25