Brian H. Annex

Brian H. Annex

Professor of Medicine and Biomedical Engineering
Division Chief, Cardiovascular Medicine

M.D. Yale University, 1985

Division of Cardiovascular Medicine
PO Box 800158
Charlottesville, VA 22908


Research Interests

Dr. Annex's laboratory has both clinical and basic research projects in area of angiogenesis (the growth of new blood vessels). This is largely focused on peripheral arterial disease (PAD) where blockages in arteries cause a series of clinical problems. His group conducts a series of translational studies which include investigations on the causes of lower extremity atherosclerosis, the mechanisms that regulate the control of collateral blood vessel formation, the impact that diabetes mellitus plays in PAD, computational modeling of growth factor pathways, as well as genetic influences. There are several clinical studies such as those testing the mechanism of exercise training as well as gene or cell based clinical investigation to promote blood vessel growth in patients with PAD. Finally, the laboratory studies other aspects of angiogenesis in the context of vascular injury such as erectile dysfunction.

Selected Publications

Dokun AO, Keum S, Hazarika S, Li Y, Lamonte GM, Wheeler F, Marchuk DA, Annex BH. A Quantitative Trait Locus (LSq-1) on Mouse Chromosome 7 Is Linked to the Absence of Tissue Loss After Surgical Hindlimb Ischemia. Circulation 2008;117:1207-15.

Xie D, Findley CM, Greenfield JM, Pippen AM, Kontos CD, Donatucci CF, Annex BH. A VEGF Trap Inhibits the Beneficial Effect of bFGF on Vasoreactivity in Corporal Tissues of Hypercholesterolemic Rabbits. J Sex Med. 2008;5:2069-2078.

Powell RJ, Simons M, Mendelsohn FO, Daniel G, Henry TD, Koga M, Morishita R, Annex BH. Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation 2008;118:58-65.

Hazarika S, Angelo M, Li Y, Aldrich AJ, Odronic SI, Yan Z, Stamler JS, Annex BH. Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis After Hind-Limb Ischemia. Arterioscler Thromb Vasc Biol. 2008;28:2144-2150.

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