&cmd &dopt Publications | The Peirce-Cottler Laboratory | Dr. Shayn Peirce | University of Virginia | Department of Biomedical Engineering
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Publications

HEARD AROUND THE LAB:


Publications

2016:


Seaman SA, Cao Y, Campbell CA, Peirce SM. (2016) Macrophage recruitment and polarization during collateral vessel remodeling in murine adipose tissue. Microcirculation. 23(1):75-87. [Pubmed Abstract]

Corliss BA, Azimi MS, Munson J, Peirce SM, Murfee WL. (2016) Macrophages: An Inflammatory Link between Angiogenesis and Lymphangiogenesis. Microcirculation. 23(2):95-121. [Pubmed Abstract]

Seaman SA, Tannan SC, Cao Y, Peirce SM, Gampper TG. (2016) A closer look at Cryolipolysis-Induced Paradoxical Adipose Hyperplasia and cellular effects—evidence of more than adipocyte cell death. Aesthetic Surgery Journal. 36(1):NP6-NP13. [Pubmed Abstract]

Chappell JC, Cluceru JG, Nesmith JE, Mouillesseaux KP, Bradley V, Hartland C, Hashambhoy-Ramsay YL, Walpole JB, Peirce SM, Mac Gabhann F, Bautch VL. (in press) Flt-1 (VEGFR-1) Coordinates Discrete Stages of Blood Vessel Formation. Cardiovascular Research.

Bruce A, Cao Y, Henry C, Peirce SM, Laughon K. (in press) Pre-clinical assessment of safety and efficacy of fluorescent dye for detecting dermal abrasions in a murine model. Journal of Forensic Sciences.

Martin K., Virgilio K., Peirce-Cottler S., Blemker S. (in press) Computational modeling of muscle regeneration and adaptation to advance muscle tissue regeneration strategies. Cells, Tissues, Organs.

2015:


Walpole J, Chappell JC, Clucerub JG, Mac Gabhann F, Bautch VL, Peirce SM. (2015) Agent-based model of angiogenesis simulates capillary sprout initiation in multicellular networks. Integrative Biology. 7: 987-997. *Cover illustration [Pubmed Abstract]

Martin KS, Blemker SS, Peirce SM. (2015) Agent-Based Computational Model of Skeletal Muscle Investigates Muscle-Specific Responses to Disuse-Induced Muscle Atrophy. J Appl Physiol. 118(10):1299-309. [Pubmed Abstract] June 2015 "Editor's Pick" *** See editorial: G. An (2015) Integrating physiology across scales and formalizing hypothesis exploration with agent-based modeling. J Appl Physiol. 118(10):1191-2. [Pubmed Abstract]***

Virgilio KM, Martin KS, Peirce SM, Blemker SS. (2015) Multi-scale models of skeletal muscle reveal the complex effects of muscular dystrophy on tissue mechanics and damage susceptibility. Interface Focus. 5(2):20140080. [Pubmed Abstract]

Murfee WL, Sweat RS, Tsubota K , Mac Gabhann F, Khismatullin S, Peirce SM. (2015) Applications of computational models to better understand microvascular remodeling. Interface Focus. 5(2):20140077. [Pubmed Abstract]

Heuslein JL, Li X, Murrell KP, Annex BH, Peirce SM, Price RJ. (2015) Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Rarefaction and Estimation of Skeletal Muscle Perfusion in Peripheral Arterial Disease. Microcirculation. Apr 10. doi: 10.1111/micc.12203. [Epub ahead of print] [Pubmed Abstract]

Cronk S, Mendel TA, Hoehn KL, Ray CH, Bruce A, Guendel AM, Herman IM, Peirce SM, Yates PA. (2015) Adipose-derived stem cells from diabetic sources show impaired vascular stabilization in the treatment of diabetic retinopathy. Stem Cells Translational Medicine. 4(5):459-67. [Pubmed Abstract]

Seaman SA, Tannan ST, Cao Y, Peirce SM, Lin KY. (2015) Differential effects of processing time and duration of collagenase digestion on human and murine fat grafts. Journal of Plastic Surgery Research. Aug;136(2):189e-99e. [Pubmed Abstract]

Adamson SE, Meher AK, Chiu Y, Sandilos JK, Oberholtzer NP, Walker NN, Hargett SR, Seaman SA, SM Peirce-Cottler, Isakson BE, Macnamara CA, Keller SR, Harris TE, Bayliss DA, Leitinger N. (in press) Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. Molecular Metabolism. 4(9):610-8. [Pubmed Abstract] *Cover illustration

2014:


Bruce AC, Kelly-Goss MR, Heuslein JL, Meisner JK, Price RJ, Peirce SM. (2014) Monocytes are recruited from venules during arteriogenesis in the murine spinotrapezius ligation model. Arterioscler Thromb Vasc Biol. 34(9):2012-22. [Pubmed Abstract]

Kelly-Goss MR, Sweat RS, Stapor PC, Peirce SM, Murfee WL. (2014) Targeting Pericytes for Angiogenic Therapies. Microcirculation. May;21(4):345-57. [Pubmed Abstract]

Agrawal A, Shang H, Parker AM, Ying N, Peirce SM, Katz AJ. (2014) Human adipose-derived cells demonstrate short-lived persistence after implantation in both an immunocompetent and an immunocompromised murine model. Stem Cell Research & Therapy. 5(6):142. [Pubmed Abstract]

Kesser BW, Hallman M, Murphy L, Tillar M, Keeley M, Peirce S. (2014) Interval vs massed training: how best do we teach surgery? Otolaryngol Head Neck Surg. 150(1):61-7. [Pubmed Abstract]

Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Peirce-Cottler SM, Rembold CM, Annex BH, Yan Z. (2014) Extracellular Superoxide Dismutase Ameliorates Skeletal Muscle Abnormalities, Cachexia and Exercise Intolerance in Mice with Congestive Heart Failure. Circ Heart Fail. 7(3):519-30. [Pubmed Abstract]

Ogle ME, Sefcik LS, Awojoodu AO, Chiappa NF, Lynch K, Peirce-Cottler S, Botchwey EA. (2014) Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. Acta Biomater. 10(11):4704-14. [Pubmed Abstract]

2013:


Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey E. (2013) Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13785-90. [Pubmed Abstract]

Mendel TA, Clabough EBD, Kao DS, Demidova-Rice TN,Durham JT, Zotter BC, Seaman SA, Cronk SM, Rakoczy EP, Katz AJ, Herman IM, Peirce SM, Yates PA. (In press) Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy. PLoS One. 8(5):e65691. [Pubmed Abstract]

Walpole J, Papin JA, Peirce SM. (2013) Multiscale Computational Models of Complex Biological Systems. Annu Rev Biomed Eng. 15:137-54. [Pubmed Abstract]

Guendel AM, Martin KS, Cutts J, Foley PL, Bailey AM, Mac Gabhann F, Cardinal TR, Peirce S. (2013) Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling. J Vis Exp. Mar 3;(73):e50218. doi: 10.3791/50218. [Pubmed Abstract]

2012:


Peirce SM, Mac Gabhann F, Bautch VL. (2012) Integration of experimental and computational approaches to sprouting angiogenesis. Curr Opin Hematol. 2012 May;19(3):184-91. doi: 10.1097/MOH.0b013e3283523ea6. [Pubmed Abstract]

Taylor AC, Mendel TA, Mason KE, Degen KE, Yates PA, Peirce SM. (2012) Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy.13;53(9):5462-70. doi: 10.1167/iovs.11-8599. [Pubmed Abstract]

Yang M, Stapor PC, Peirce SM, Betancourt AM, Murfee WL. (2012) Rat mesentery exteriorization: a model for investigating the cellular dynamics involved in angiogenesis. J Vis Exp. 2012 May 20;(63):e3954. doi: 10.3791/3954. [Pubmed Abstract]

Morris E, Kesser BW, Peirce-Cottler S, Keeley M. (2012) Development and Validation of a Novel Ear Simulator to Teach Pneumatic Otoscopy.Simul Healthc. Feb;7(1):22-6. doi: 10.1097/SIH.0b013e31822eac39. [Pubmed Abstract]

Hayenga HN, Thorne BC, Yen P, Papin JA, Peirce SM, Humphrey JD. (2012) Multiscale Computational Modeling in Vascular Biology: From Molecular Mechanisms to Tissue-Level Structure and Function. Springer-Verlag Berlin Heidelberg. Series 8415. Stud Mechanobiol Tissue Eng Biomater. doi: 10.1007/8415_2012_147

2011:


Bruce AC, Peirce SM. (2011) Exogenous Thrombin Delivery Promotes Collateral Capillary Arterialization and Tissue Reperfusion in the Murine Spinotrapezius Muscle Ischemia Model. Microcirculation. Feb;19(2):143-54. doi: 10.1111/j.1549-8719.2011.00138.x. [Pubmed Abstract]

Amos PJ, Mulvey CL, Seaman S, Walpole J, Degen KE, Shang H, Katz AJ, Peirce-Cottler SM. (2011) Hypoxic Culture and In Vivo Inflammatory Environments Affect the Assumption of Pericyte Characteristics by Human Adipose and Bone Marrow Progenitor Cells. Am J Physiol Cell Physiol. Dec;301(6):C1378-88. doi: 10.1152/ajpcell.00460.2010. [Pubmed Abstract]

Hayenga HN, Thorne BC, Peirce SM, Humphrey JD. (2011) Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation. Ann Biomed Eng. 2011 Nov;39(11):2669-82. Epub 2011 Aug 2. [Pubmed Abstract]

Thorne BC, Hayenga HN, Humphrey JD, Peirce SM. (2011) Toward a multi-scale computational model of arterial adaptation in hypertension: verification of a multi-cell agent based model. Front Physiol. 2011;2:20. Epub 2011 May 9. [Pubmed Abstract]

Hashambhoy YL, Chappell JC, Peirce-Cottler SM, Bautch VL, Mac Gabhann F. (2011) Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients. Front Physiol. 2011;2:62. doi: 10.3389/fphys.2011.00062. [Pubmed Abstract]

Seaman ME, Peirce SM, Kelly K. (2011) Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis. PLoS One. 2011;6(6):e20807. Epub 2011 Jun 9. [Pubmed Abstract]

Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA. (2011) Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. Tissue Eng. Part A. Mar;17(5-6):617-29. Epub 2010 Nov 9. [Pubmed Abstract]

Billaud M, Ross JA, Greyson MA, Bruce AC, Seaman SA, Heberlein KR, Han J, Best AK, Peirce SM, Isakson BE. (2011) A new method for in vivo visualization of vessel remodeling using a near-infrared dye. Microcirculation. Apr;18(3):163-71. doi: 10.1111/j.1549-8719.2011.00085.x. [Pubmed Abstract]
*Cover illustration

Benedict KF, Mac Gabhann F, Amanfu RK, Chavali AK, Gianchandani EP, Glaw LS, Oberhardt MA, Thorne BC, Yang JH, Papin JA, Peirce SM, Saucerman JJ, & Skalak TC. (2011) Systems Analysis of Small Signaling Modules Relevant to Eight Human Diseases. Ann Biomed Eng. 39(2):621-35. [Pubmed Abstract]

2010:


Taylor AC, Seltz LM, Yates PA, & Peirce SM. (2010) Chronic Whole-body Hypoxia Induces Murine Retinal Angiogenesis and Microvascular Remodeling. Microvascular Research. 79(2):93-101. [Pubmed Abstract]
*Cover illustration

Amos PJ, Kapur SK, Stapor PC, Hulan S, Bekiranov S, Rodeheaver GT, Peirce SM, & Katz AJ. (2010) Human Adipose-derived Stem Cell Aggregates as a Therapy for Healing Diabetic Wounds. Tissue Engineering Part A. 16(5):1595-606. [Pubmed Abstract]

Petrie Aronin C, Sefcik LS, Tholpady A, Sadik KW, Tholpady SS, Macdonald TL, Wamhoff BR, Peirce SM, Lynch KR, Ogle R, & Botchwey E. (2010) FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Eng Part A. Jun;16(6):1801-9. [Pubmed Abstract]

Mac Gabhann F & Peirce SM. (2010) Anatomical Predictions of Capillary Arterialization in Mouse Spinotrapezius Muscle Based on Mouse Strain. Microcirculation. 17:333-47. [Pubmed Abstract]

Glaw J, Skalak TC, & Peirce SM. (2010) Inhibition of Canonical Wnt Signaling in Microvascular Growth and Remodeling of an Adult Rat Mesenteric Model. Microcirculation. 17:348-57. [Pubmed Abstract]

2009:


Bailey AM, Lawrence MB, Shang H, Katz AJ, & Peirce SM. (2009) Agent-based Model of Therapeutic Adipose-derived Stromal Cell Trafficking During Ischemia Predicts P-selectin Mediated Rolling Ability. PLoS Computational Biology. Feb 5 (2):e1000294. [Pubmed Abstract]

Volsky PG, Hughley B, Peirce SM, & Kesser BW. (2009) Construct Validity of a Simulator for Myringotomy and Ventilation Tube Insertion. Otolaryngology-Head and Neck Surgery, Otolaryngol Head Neck Surg. 41(5):603-608.e1. [Pubmed Abstract]

2008:


Chavali AK, Gianchandani EP, Tung KS, Lawrence MB, Peirce SM, & Papin JA. (2008) Modeling of complex immunological systems for characterizing global emergent properties. Trends in Immunology. 29(12):589-99. [Pubmed Abstract]
*Cover illustration

Peirce SM. (2008) Computational and Mathematical Modeling of Angiogenesis. Microcirculation. 15(8):739-51, 2008. PMID: 18720228. [Pubmed Abstract]

Bailey A.M., O'Neill T.J.t., Morris C.E., Peirce S.M. (2008). Arteriolar remodeling following ischemic injury extends from capillary to large arteriole in the microcirculation. Microcirculation 5,389-404. [Pubmed Abstract]
*Cover illustration

Birchenough S.A., Rodeheaver G.T., Morgan R.F., Peirce S.M., Katz A.J. (2008). Topical poloxamer-188 improves blood flow following thermal injury in rat mesenteric microvasculature. Ann Plast Surg 5,584-588. [Pubmed Abstract]

Amos P.J., Shang H., Bailey A.M., Taylor A., Katz A.J., Peirce S.M. (2008). IFATS Series: The Role of Human Adipose-Derived Stromal Cells in Inflammatory Microvascular Remodeling and Evidence of a Perivascular Phenotype. Stem Cells. [Pubmed Abstract]

Amos PJ*, Bailey AM*, Shang H, Katz AJ, Lawrence MB, and Peirce SM. Functional binding of human adipose-derived stromal cells: Effecs of extraction method and hypoxia pretreatment. Annals of Plastic Surgery. Volume 60(4), April 2008, pp 437-444. [Pubmed Abstract]
*Authors contributed equally to this work

Thorne BC, Bailey AM, DeSimone DW, & Peirce SM. (2008). Agent-based Modeling of Multi-Cell Morphogenic Processes During Development. Embryo Today, Jan; 81(4):344-353. [Pubmed Abstract]

2007:


Robertson SH, Smith CK, Langhans AL, McLinden SE, Oberhardt MA, Jakab KR, Dzamba B, DeSimone DW, Papin JA, & Peirce SM. (2007). Multiscale Computational Analysis of Xenopus laevis Morphogenesis Reveals Key Insights of Systems-Level Behavior. BMC Syst Biol, Oct; 1:46. [Pubm ed Abstract]

Thorne, B. C., Bailey, A. M. and Peirce, S. M. (2007). Combining experiments with multi-cell agent- based modeling to study biological tissue patterning. Brief Bioinform, Jul; 8(4): 245-57. [Abstract] [Full Text] [PDF]

Taylor, A. C., Murfee, W. L. and Peirce, S. M. (2007). EphB4 expression along adult rat microvascular networks: EphB4 is more than a venous specific marker. Microcirculation 14, 253-67. [Pubmed Abstract]

Bailey, A. M.*, Thorne, B. C.* and Peirce, S. M. (2007). Multi-cell Agent-based Simulation of the Microvasculature to Study the Dynamics of Circulating Inflammatory Cell Trafficking. Ann Biomed Eng 35, 916-36. [Pubmed Abstract] [Supplemental Info]
*Authors contributed equally to this work

2006:


Peirce-Cottler, S.M., T.S. Skalak, and J.A. Papin. 2006. Multi-scale systems integration from cells to tissues: coupling intracellular network analysis with tissue-patterning simulations. IBM Journal of Research and Development. [Full text | PDF]

Murfee WL, Rehorn MR, & Peirce SM, Skalak TC, 2006. Perivascular Cells Along Venules Upregulate NG2 Expression During Microvascular Remodeling. Microcirculation. 13: 261-273. [Pubmed Abstract]
*Cover illustration

2005:


Murfee WL, Skalak TC, & SM Peirce, 2005. Differential Arterial/Venous Expression of NG2 Proteoglycan in Perivascular Cells Along Microvessels: Identifying a Venule-Specific Phenotype. Microcirculation 12: 151-160. [Pubmed Abstract]

2004:


Peirce SM*, Van Gieson EJ*, & Skalak TC, 2004. Multicellular Simulation Predicts Microvascular Patterning and In Silico Tissue Assembly. FASEB Journal.10.1096/fj.03-0933fje. *Authors contributed equally to this work. [Pubmed Abstract]
*Cover illustration

Longo DM*, Peirce SM*, Skalak TC, Marsden M, Davidson LA, Dzamba BJ, & DeSimone DW, 2004. Computational Automata Simulation of Blastocoel Roof Thinning In the Xenopus laevis Embryo. Developmental Biology. 271: 210-222. *Authors contributed equally to this work.

2003:


Peirce SM & Skalak TC, 2003. Microvascular Remodeling: A Complex Continuum Spanning Angiogenesis to Arteriogenesis. Microcirculation. 10: 99-111. [Pubmed Abstract]

Peirce SM, Price RJ, & Skalak TC, 2003. Spatial and Temporal Guidance of Angiogenesis and Arterialization. American Journal of Physiology-Heart & Circulatory Physiology. 286: H918-H925.

2002:


Hirschi KK, Skalak TC, Peirce SM, & Little CD, 2002. Vascular Assembly in Natural and Engineered Tissues. Annals New York Academy of Sciences. 961: 223-242. [Pubmed Abstract]

2000:


Peirce SM, Skalak TC, & Rodeheaver G, 2000. Ischemia-Reperfusion Injury in Chronic Pressure Ulcer Formation: A Skin Model in the Rat. Wound Repair and Regeneration, 1(8): 90-97. [Pubmed Abstract]

Peirce SM, Skalak TC, MacDonald T, Reiger J, & Linden J, 2000. Selective A2A Adenosine Receptor Activation Reduces Skin Pressure Ulcer Formation and Inflammation. American Journal of Physiology- Heart & Circulatory Physiology. 281(1): H67-74. [Pubmed Abstract]

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