Masthead for the Peirce-Cottler Lab at the University of Virginia

Welcome to the Peirce-Cottler Laboratory
in the Department of Biomedical Engineering
at the University of Virginia

Nearly every tissue in the body needs a blood supply, and that demand is met by a network of interconnected blood vessels called the microcirculation. The microcirculation is a highly adaptable system of small blood vessels that are a tenth of the diameter of a human hair–-you need a microscope to see them–-and there are over a million microvessels in a single gram of tissue. Microvascular growth and remodeling are important processes in nearly every major disease, including diabetes, heart disease, peripheral vascular disease, stroke, neurodegenerative diseases, and cancer. In our lab, we develop and use experimental and computational techniques to study and design new approaches for growing and regenerating injured and diseased tissues by manipulating the structure and composition of the microvasculature.

News from the Lab

CONGRATULATIONS TO: Dr. Scott Seaman, Ph.D. for successfully defending his dissertation on February 19, 2016; Dr. Kyle Martin, Ph.D. for successfully defending his dissertation on December 9, 2015; and Dr. Shayn Peirce-Cottler for being elected to the AIMBE College of Fellows.

NEW TECHNOLOGY IN THE LAB: Welcome our new 3D-Bioprinter from Switzerland! The 3DDiscovery by RegenHu is one of only three of its kind in the United States! Here's a link to a movie of our 3D-Bioprinter in action: Peirce-Cottler Lab 3D- Bioprinter

RECENT INVENTION BY THE LAB: United States Patent Application No. 8,980,631 was issued on March 17th: " High-throughput culture and transfer device and method." Co-Inventors: Blair Stocks, Shayn Peirce-Cottler, Adam Katz.

RECENT PAPERS BY THE LAB: Walpole J, Chappell JC, Clucerub JG, Mac Gabhann F, Bautch VL, Peirce SM. (2015) Agent-based model of angiogenesis simulates capillary sprout initiation in multicellular networks. Integrative Biology. 7: 987-997. [Pubmed Abstract] *Cover illustration*

Martin KS, Blemker SS, Peirce SM. (2015) Agent-Based Computational Model of Skeletal Muscle Investigates Muscle-Specific Responses to Disuse-Induced Muscle Atrophy. J Appl Physiol. 118(10):1299-309. [Pubmed Abstract] *June 2015 "Editor's Pick"*

See editorial: G. An (2015) Integrating physiology across scales and formalizing hypothesis exploration with agent-based modeling. J Appl Physiol. 118(10):1191-2. [Pubmed Abstract]

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