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Sunil Unnikrishnan, M.S.
Research Interests: My research interests lie in studying the effect of the endothelial surface layer (a hydrated membrane-bound negatively-charged carbohydrate-rich layer) on the hemodynamics in major vessels like the femoral artery. In addition to exerting a biophysical influence by way of its effect on the resistance and viscosity in the microvasculature, it has also been shown to play a role in leukocyte and platelet interactions with the vessel wall. The components of the layer have been implicated in mechanotransduction. Its role in atherosclerosis is still unclear, though an association between decreased thickness of the layer and regions of atherosclerosis has been reported. We use intravital microscopy in conjunction with micro-PIV (Particle image velocimetry) to elucidate the physical role of the layer in large arteries. |
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