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Elena Galkina, Ph.D
Research Interests: In the past decade a growing body of data shows that B- and T-cells, macrophages, NKT-cells and dendritic cells participate in the development of atherosclerosis. This strongly suggests that the innate and adaptive immune systems are deeply involved in the initiation and progression of atherosclerosis. However, the exact mechanisms of the recruitment, activation, proliferation and retention of different types of immune cells within the aortic wall remain unclear. The aims of my projects are to identify the immune cell composition of the aortic wall under normal/non-inflamed conditions and during atherosclerosis, and the mechanisms of migration and retention of lymphocytes within the aortic wall. I am also interested in the mechanisms that lead to the formation of lymphoid-like structures within the aortas and local immune response during the development and progression of atherosclerosis. |
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