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Xitong Dang, Ph.D
Research Interests: P-selectin glycoprotein ligand-1 (PSGL-1), a ligand for P-, E-, and L-selectins, plays an important role in recruitment of leukocytes into inflammatory sites. This leukocyte recruitment is also involved in certain diseases such as ischemia-reperfusion injury and chronic murine ileitis. Studies have also shown that PSGL-1 acts as a signal molecule, transmitting signals directly into leukocytes. PSGL-1 is broadly expressed in hematopoietic cells, non- hematopoietic cells such as stomach, ovary, skeletal muscle, liver, kidney and etc., and venules of mesenteric lymph node and small intestine. So deciphering the transcriptional regulation of PSGL-1 would improve our knowledge in understanding its tissue-specific expression, the mechanism of leukocyte recruitment and find molecular targets to effectively modify and eventually treat these PSGL-mediated diseases. |
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