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The following are all of the comments and reviews made for the entire site. Each one refers or is responding to a specific page (listed in the "page" column) which can be accessed by clicking on the link. The entire volume of reviews have been collected here on one page so that one may browse all of the information posted to the site at once.

Comment Page

Title:
Posted by Adrian at 2008-07-29 14:08:13

This page is awesome and I have been visiting here for several times. Just a question about P selectin; dose anyone know if p selectin from platelets and endothelial cells are the same or different? Thanks.

Title: P-Selectin and TNFa in humans
Posted by Jessica at 2008-06-30 09:21:42

This page is excellent. However, I am not sure that TNFa transcriptionally up-regulates P-selectin expression in human cells. I believe this is because the P-selectin gene in humans lacks the traditional NFkB promoter. In contrast, the murine gene does contain this promoter, and P-selectin is up-regulated by TNFa in the mouse.

Title: lol
Posted by annoymouss at 2008-05-25 03:47:42

k wow fake info

Title: permission
Posted by david o Donnell at 2008-03-25 10:14:49

I find your site very informative.The figure describing the leukocyte adhesion cascade is very good. I am writing my thesis about inflammatory responses and need a good illustration of the adhesion cascade. My question is, if I could have your permission to use your illustration of the adhesion cascade in the publication of my thesis. Sincerely david o Donnell M.D.

Title: Harvard BioVisions video of leukocyte extravasation
Posted by Ron at 2007-11-14 17:41:49

There is an amazing video done by the Harvard BioVisions project that shows the whole cascade with stunning computer graphic animation at: http://multimedia.mcb.harvard.edu

Title:
Posted by Giovanna at 2007-11-04 09:58:41

i wish i could see transmigration pictures. thanks

Title: uh
Posted by texas at 2007-04-15 13:40:21

it didnt even answer my question

Title: Firm Adhesion
Posted by Mellisa at 2006-12-19 03:23:33

I like this page, the information seems very vast and yet well comprehended.But I couldn't see the link of tne "Firm Adhesion" picture.Would you like help me?

Title: cell adhesion molecules
Posted by ayo ehirim at 2006-11-10 11:34:48

hi, im currently writing a dissertation and would like permission to use your diagram on leukocyte rolling as i have seen the mechanical illustration and is quite informative. i know this is the comment box, but i didnt know who or where to contact regards, A Ehirim

Title: leukocyte esterase
Posted by E. guidali at 2006-10-07 12:15:43

what is it and what is normal range?

Title: yup
Posted by tim at 2006-10-04 13:29:41

good stuff, thanks for the info. ummm, go chargers!

Title: epithelim
Posted by stuart stickley at 2006-07-22 20:28:24

hi some research says that excess iron levels in males contribute to the harding of vessal lining( i presume the epithilium is invoved) and can lead to heart disease. i have high iron levels, i also have constant headaches- i'm always told they are stress related. i would like to know if you think high iron levels etc. are associated to my headaches? thanks

Title:
Posted by Aliakbar Taherian at 2006-06-12 16:09:23

Hi These are nice pictures. A few lines of explanation would help to understand better these pitures. Thanks Ali

Title:
Posted by zunooni at 2006-05-21 03:28:30

Hi I was woundering if you would mind sending me glycosilation of these cells. Thanks a million

Title: endothelium is a strange substance
Posted by jumanji at 2006-04-20 20:16:10

i think endothelium is so complicated substance & no one would give it the right defination , but we may say that it has a great secret which maintain our life good , our blood flow is normal & our circulation is ok

Title: Leukocyte adhesion
Posted by André at 2006-04-03 09:57:47

I have been looking at various sites. No site mentions the exact method to use if one needs to look at a possible deficiency. e.g. Stimulate whole blood for 1 hour with fMLP at 37°C and then stain with monoclonal antibodies at room temperature, etc.

Title: endothelium
Posted by ruqiaya at 2006-03-22 05:30:18

a nice definition,but lacks a diagram.could u plz let me kn abt ,are there some endothelial cels lining the trachea,what is its role in diseases like asthma and flu virus?and abt its receptors?hope to get a feedback from u very soon.thanks

Title:
Posted by viewer at 2006-03-21 15:19:51

the link under eosinophils does not work, the link is missing an 's' at the end of chemmoattractents.

Title: immunoglobin
Posted by kiran at 2006-02-26 23:47:38

send me information of immunoglobin,mhci,mhcii ,and other

Title: Endothelium
Posted by Chuck Barnett at 2006-02-08 10:56:18

AMAZING how the endothelium just evolved to be and do all it is and does! ;)

Title: endothelium
Posted by harry at 2006-02-01 20:55:00

good definition.

Title:
Posted by suneel at 2005-12-23 20:05:24

please try to add a more detailed description on the role of integrins in cell adhesion

Title:
Posted by sharad at 2005-12-15 12:07:01

loved this page the information seems very vast and yet well comprehended. also after reading this i feel there is stil a lott to find about the leukocyte adhesion molecules and their interaction with the various cytokines.

Title: Inflammation
Posted by the pharmacy_student at 2005-12-07 08:58:25

This is the most incredible page on this topic that I have ever seen!!!

Title: Endothelium
Posted by Kate Divers at 2005-10-09 10:58:34

What affect does endothelium have on gas exchange? For example, does it control what passes in and out of a cell, or is it completely unrelated?

Title:
Posted by rmacgill at 2005-09-27 05:00:06

good page with detailed information. Was useful to read.

Title: Integrin Activation page
Posted by Charnell Sommers at 2005-07-01 10:46:47

http://bme.virginia.edu/ley/integrin_activation.html below each schematic there is a <caption> but no information

Title: ankle inflammation
Posted by M. Putnam at 2005-04-20 14:21:44

Could leucocyte adhesion potentially cause heart attacks or strokes? Is there a natural remedy for inflammation (following a broken ankle 5 mos. ago in a mid-age woman.) I have heard that emu oil, glucosamine, and DMSO could be helpful??

Title: ENDOTHELIM
Posted by MAURICE GAGNON at 2004-12-04 11:40:25

I have angina symthomes when I first start to exercise or I do tasks requiring a quick burst of energy like going up a stairs quickly. The sympthones disappear if ùi continue the exercise. I had a coronagraphy done and it reveals that there was only a 20% blockage in one of the artery, not enough to cause angina. Could this endothelim cause these sympthomes.

Title: inflammation
Posted by vandana at 2004-11-22 12:28:25

im very much interested in inflammation .plz let me know more about the key cell involved in inflammation.

Title: inflammation
Posted by dilip at 2004-10-06 05:39:51

please, send me more information on this topic. and also thank you for this information.

Title: regulation of blood flow
Posted by Anneka at 2004-10-01 10:10:15

I dont quite understand the physical/chemical properties of the endothelium that allows it to regulate blood flow and systematic blood pressure?

Title: How important ?
Posted by Russell Booth at 2004-10-01 06:48:15

How important is the endothilium? What are the main tasks it performs? I know it creates a barrier to stop diffusions but does it also support the lumen and the actual blood vessel itself, i am a year 11 school student so be easy on me ;)

Title: endothelial cells count
Posted by intan at 2004-09-30 10:41:15

How much total endothelial cells count in human body (man 70 kg). If possible, please give references. Thanks.

Title: endothelium
Posted by ihsan at 2004-09-25 18:59:10

please can you tell me the involvement of endothelium in hemostasis under pathological condition thanx

Title: inflammation
Posted by Kathy at 2004-09-06 20:35:16

The information was interesting. I am wondering if anyone out there has information on FLUIDJOINT. The new IgG immunoglobin dietary supplement. Evidently it interacts with Neutrophils in some way. I am a nurse and pulled out my pathophysiology book and I am a bit confused on how this could help. What is amazing however, is that I have started it and am finding tremendous relief in joint pain and stiffness. I am hoping this is not a placebo effect. Am cautiously optimistic but if this improved feeling is from the FLUIDJOINT, I am very happy. Also, is there any adverse effect to the liver from ingesting IgG immunoglobin?

Title: bnh
Posted by bassma at 2004-09-05 09:50:21

how the endothelium become activated

Title: inflammation
Posted by teresa alarcon at 2004-09-03 16:04:10

LA PAGINA ES EXCELENTE. GRACIAS

Title: the leukocyte adhesion cascade
Posted by Ashwin Raut at 2004-09-01 09:22:10

Thank you very much for a very simplified and lucid educative material.

Title: in jail
Posted by lindroos at 2004-08-10 05:37:26

Would it be more appropriate to create coronary stent, that would not force endothelium (and the vessel wall) to certain shape, like metal stents do? I have been thinking what would it be like...

Title: DETEMINATION DE LA CTIVITE ANTI INGLAMMATOIRE DANS UNE PLANTE
Posted by ESPERANCE at 2004-08-07 07:13:07

comment determiner l'activite antiinflammatoire dans une plante.

Title: haematological and biochemical effects of xylazine in sheep
Posted by dr ghazanfar at 2004-07-27 13:03:40

plz send me latest information about this topic

Title: haematological and biochemical effects of xylazine in sheep
Posted by dr ghazanfar at 2004-07-27 13:03:40

plz send me latest information about this topic

Title: inflammation general
Posted by dr ghazanfar at 2004-07-27 12:54:36

plz send me latest information about this topic

Title: Is Caffeine a Factor?
Posted by Jo Andrews at 2004-07-09 07:54:34

Is there research that indicates caffeine is a culprit in deteriorating the endothelium? If so, what are foods that promote/preserve a healthy endothelium? Thanks.

Title:
Posted by Peter Danielsson at 2004-07-07 04:50:45

I find your site very informative.The figure describing the leukocyte adhesion cascade is very god. I am writing my thesis about inflammatory response in peripheral arterial disease and need a god illustration of the adhesion cascade. My question is, if I could have your permission to use your illustration of the adhesion cascade in the publication of my thesis. Sincerely Peter Danielsson M.D

Title: Endothelium
Posted by Jeanine Lawrence at 2004-07-06 09:56:37

I am also interested in what types of foods or vitamins will promote endothelium health since I am having chronic pericarditis and have severe reactions to the meds, Indomethecin and Bextra. Thank you.

Title: Endothelium
Posted by Bill Hall at 2004-06-24 09:47:24

Is there such a condition as enothelial hyperplasia?

Title: capillaries
Posted by Melanie at 2004-06-19 08:30:30

Since capillaries are a single layer of endothelium are they considered to have a tunica or lunicas like veins and arteries?

Title: stoke/TIA
Posted by Joel R at 2004-06-04 10:30:36

What connection might there be between endothelium and a TIA event? If there is a connection, is Plavix the solution or is enhancement of endothelium better long term solution? Thanks

Title:
Posted by Robert Albright at 2004-05-13 11:39:46

Thank you very much for this piece on inflammation, it has helped me to understand my condition. It has confirmed why my omega 3 & shark oil regimin has helped considerable. It is an anti inflammatory. Thank you, Robert

Title: Sulphasalazine
Posted by jennifer at 2004-05-03 12:46:56

I have seen two consultants about my chronic joint pain, one diagnosed Psoriatic arthritis the other Rheumatoid, both wanted me to start taking Sulphasalazine. Any advice would be very much appreciated.

Title: Thanks
Posted by Von at 2004-04-09 21:55:59

great graphics and good explainations. You helped me understand inflammation as a normal response of the body to injury.

Title:
Posted by elizabeth at 2004-04-05 16:08:52

I would like information on the adhesion of the stomach

Title: Inflammation
Posted by M Ellsworth at 2004-04-05 15:14:07

Besides injury, what causes chronic inflammation. I have heard that sugar synthesis is involved. If one eliminates all sugars from the diet is it possible to eliminate or at least reduce inflammation. My inflammation moves from one spot to another and I have yet to find good relief from the extreme pain. Ice helps but isn't convenient.

Title: Inflammation
Posted by Emma at 2004-04-01 10:31:32

This is a great presentation about inflammation. I understood it very well. My question since I take Arthrotec once a day for lower back pain. Is this pill safe enough to take on a daily bases for a long term? Seems that once I don't take it the pain comes back.Thanks

Title: Thank you
Posted by Christy at 2004-03-28 14:35:01

Thank you very much for that information. It was very vital that I got that. Thank you and have a good day, Bye. :) Sincerely, Christy Wolf

Title: inflammation
Posted by Sheryl Hay at 2004-03-27 20:02:24

I would like to learn as much as I can about inflammation. What about people like myself whose immune system is in a constant state of overdrive, but whose system is unable to throw off viruses and yeast, etc.??

Title: re: endothelium
Posted by Kristi H. at 2004-03-03 20:57:59

What types of foods or vitamins will promote endothelium health?

Title: Vioxx
Posted by John at 2004-01-27 01:51:03

I have taken Vioxx pills for two years to help me with the pain. The pain comes back and now I cant eliminate it. Are there any treatments more effective than pills? I have no redness of any kind, I do have pain and it does itch at times with minor heating in my right knee and right elbow area. But the pain goes away only when i use a cream made by "Bengay". It is a cooling cream used by many for muscle pains and etc. Please help me and let me know of any other medication that will work. Celebrex doesnt work either. Thna you,

Title: Endohtelium thickness
Posted by Zena Monica Nicholas at 2003-12-11 22:16:37

How thick is the endothelium? a. 5mm OR b. 3-5mm

Title: LADS TYPE 2
Posted by MOHAMMAD NABAVI at 2003-12-09 07:51:58

To whom it may be concern I am an pediatric immunologist and have great interest to follow the patients with immunodeficiencies. As a clinical immuonologist i have encountered with four cases of LADS type 1 ( one of them expired ) and recently a one year old boy hospitalized with multiple large echtymic lesions and high fever and also repeated seizures and can be regardede as LADS TYPE 2 . Would you please inform me more about therapeutic modalities for example fucose supplementation .

Title:
Posted by Alex at 2003-12-08 12:24:03

Nice images-- very helpful for biochemistry undergrads.

Title: inflammation cascade
Posted by Eugenio Ragazzi, M.D. - Associate professor of Pharmacology, U at 2003-12-01 07:02:20

Very nice presentation of up-to-date aspects of leukocyte adhesion cascade. This and following web pages have been very useful for a discussion together my students (Pharmacology class) during the study of the inflammation main steps. The description is very clear, and the images (beautiful) are extremely explicative and complete. Thanks!