The Cardiac Biomechanics Group focuses on the interactions between mechanics, function, and growth and remodeling in the heart. The mechanical properties of normal and diseased myocardium are important determinants of overall heart function. These mechanical properties change during growth, remodeling or disease, often in part as a response to changes in the mechanical environment. Our group studies this interplay between mechanical environment, tissue response, and heart function, not only to better understand the basis for heart disease but also to identify new opportunities to intervene.
News & Events:
What Exactly Does Your ECM Know?
Dr. Holmes was one of two investigators nationwide selected for the new AHA-Allen Distinguished Investigators program. A collaboration with Dr. Sarah Ewald in Microbiology and Dr. Zunder in BME, this project will track information flow in the cardiac extracellular matrix during aging and following myocardial infarction.
See more about the project here: https://www.youtube.com/watch?v=SQnYF7AXUr4
Has Cardiac Fibrosis Met its Match?
Dr. Saucerman and Dr. Holmes received a new joint grant from the NIH to study the systems biology of cardiac fibrosis. The project uses signaling network and agent-based models, and includes Dr. Peirce-Cottler from BME as well.
Colleen wins AHA Fellowship
Colleen Witzenburg received a 2-year Postdoctoral Fellowship from the American Heart Association to investigate the factors that drive dilation and heart failure progression following myocardial infarction.