Postdoctoral Researchers in Computational Systems Biology Positions are available with various focus areas in computational systems biology: Metabolic engineering: A major focus of the project will be to refine the genome-scale metabolic network reconstruction of Chlamydomonas reinhardtii, an alga of interest for its ability to produce hydrogen and other biofuel targets. There is also substantial interest in applying the metabolic network to pursue novel metabolic engineering hypotheses. This work is being done in collaboration with Dr. Kourosh Salehi-Ashtiani and other experimental researchers at the Center for Cancer Systems Biology at the Dana Farber Cancer Institute, Harvard Medical School. Signaling network modeling: This individual will reconstruct and analyze intracellular signaling networks of smooth muscle cells and endothelial cells. These network models will interface with an agent-based model of an atherosclerotic plaque and will be further validated by comparison with experimental measurements on ApoE -/- knockout mice. This work is being done in collaboration with Dr. Shayn Peirce-Cottler and other researchers at the University of Virginia as part of a larger investigation of plaque progression in atherosclerosis. Multiscale modeling: The primary role of this postdoctoral fellow will be to develop an approach for integrating computational models and experimental data across multiple spatial and temporal scales to investigate plaque progression in atherosclerosis. This project is in collaboration with Dr. Shayn Peirce-Cottler and other researchers at the University of Virginia, including another postdoctoral researcher in the Papin Lab (see above). Excellent communication skills and a Ph.D. in bioengineering, bioinformatics, chemical engineering, or biochemistry or molecular biology with strong experience in a quantitative field are required. Individuals with computational modeling and experimental systems biology expertise particularly relevant to the current project areas are especially encouraged to apply. The positions will remain open until filled. To apply for any of these postdoctoral positions, please send a cover letter specifying the position(s) for which you are applying, CV, brief statement of research accomplishments and career goals, and contact information for three references to Dr. Jason Papin (papin@virginia.edu). Graduate Students We are very interested in talented graduate students interested in working in the field of systems bioengineering. Contact Dr. Jason Papin (papin@virginia.edu) if interested. Undergraduate Research Projects A variety of research projects are available for undergraduate volunteers in engineering or the life sciences. Contact Dr. Jason Papin (papin@virginia.edu) if interested.